GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

9.1.6.2 Acute Eye Irritation of C16 Alpha Olefins (Rinehart 1967)
Test Substance: C16 Alpha Olefins (98.5% olefins, 1.5% saturates)
Species/strain: Rabbit/New Zealand White
Number/sex of animals: 6 males
Observation period: 24, 48 and 72 hours post instillation
Test method: US Federal Hazardous Substances Labelling Act
Draize scores of non irrigated eyes:
Animal 24 hours
Time after instillation
48 hours 72 hours
Conjunctiva r c d r c d r c d
1 0 0 0 0 0 0 0 0 0
2 1 0 0 0 0 0 0 0 0
3 1 0 0 1 0 0 0 0 0
4 1 0 0 0 0 0 0 0 0
5 1 0 0 0 0 0 0 0 0
6 0 0 0 0 0 0 0 0 0
Cornea All individual scores were zero
Iris All individual scores were zero
1 see Attachment 1 for Draize scales
r = redness c = chemosis d = discharge.
Ocular effects: Transient conjunctival redness;
No iridial or conjunctival effects noted (all individual scores
were zero).
Mean group score
(24, 48 & 72 hour
observation):
Corneal opacity: 0.0
Iridial inflammation: 0.0
Conjunctival redness: 0.3
Conjunctival chemosis: 0.0
Result: C16 Alpha Olefins were slightly irritating to the eyes of
rabbits
FULL PUBLIC REPORT 26 April 2000
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