GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

9.1.5.9 Evaluation of Primary Skin Irritation in Humans of Neodene 18 alpha
olefin (HEDSET 1-octadecene)
Test substance: Neodene 18 alpha olefin (1-octadecene)
Number/sex of volunteers: 12 females, 6 males
Procedure: Each volunteer received to the upper arm 0.2 mL (100%,
25%, 10% and 1% dilution in mineral oil) of test substance
in a semi occluded patch for an exposure period of 24 hours
Sodium lauryl sulphate (0.25% in water) served as the
control.
Outcome: Test sites were scored at 30 minutes and 24 hours after patch
removal.
Test substance at 100%: at the 30 minute observation, 16/18
volunteers exhibited moderate to strong erythema, oedema
and papules. At 24 hours, 17 volunteers showed similar
signs and 9 of these had effects spreading beyond the
application site. Mean score: 4.28.
Test substance at 25%, 10% and 1%: no evidence of
irritation. Mean score:0.
Control: two volunteers showed mild to moderate erythema.
Mean score:0.22.
Result: Neodene 18 alpha olefin was reported irritating to human
skin
9.1.6 Eye Irritation
9.1.6.1 Acute Eye Irritation of C12-C16 Alpha Olefins (Rinehart 1967)
Test Substance: C12-C16 Alpha Olefins (98.5% olefins, 1.5% saturates)
Species/strain: Rabbit/New Zealand White
Number/sex of animals: 6 males
Observation period: 24, 48 and 72 hours post instillation
Test method: US Federal Hazardous Substances Labelling Act
FULL PUBLIC REPORT 26 April 2000
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