GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
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9.1.5.5 Acute Dermal Irritation of Gulftene <strong>18</strong> (Safepharm Laboratories Limited<br />
1996)<br />
Test substance: Gulftene <strong>18</strong> (1-octadecene)<br />
Species/strain: Rabbit/New Zealand White<br />
Number/sex of animals: 5 males, 1 female<br />
Observation period: 1, 24, 48, 72, 96 hours, 7 and 14 days post exposure<br />
Method of administration: A single semi occluded application of 0.5 mL of the neat test<br />
substance to intact skin; after 4 hours residual test substance<br />
was removed by gentle swabbing with 74% industrial grade<br />
methylated spirits;<br />
A contralateral area of untreated skin served as the control<br />
site. Control sites were similarly swabbed.<br />
Test method: OECD TG 404<br />
Draize scores:<br />
Time after Animal #<br />
treatment 1 2 3 4 5 6F<br />
Erythema/Eschar Formation<br />
30 minutes 1R 1R 2R* 1R* 1R 1R<br />
24 hours 1R 1R 2R 2R 2R 1R<br />
48 hours 1R 1 2R 2 2 1R<br />
72 hours 1R 1 2R 2 2 1<br />
96 hours 1DR 1 2DR 2D 1D 1D<br />
7 days 0D 0D 0Cf 0Cf 0D 0D<br />
14 days 0 0 0 0 0 0<br />
Oedema<br />
30 minutes 1 1 1 1 0 0<br />
24 hours 1 0 2 1 2 1<br />
48 hours 0 0 2 1 2 0<br />
72 hours 0 0 2 1 2 0<br />
96 hours 0 0 2 1 1 0<br />
7 – 14 days All individual scores were zero<br />
a see Attachment 1 for Draize scales. F = female. D = desquamation.<br />
R = reaction extends up to 5 cm beyond treatment site. Cf = crust formation.<br />
* = very slight erythema noted at corresponding control site.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 45 of 100
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