GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

Draize scores:
Time after Animal #
treatment 1 2 3 4 5 6F
Erythema/Eschar Formation
30 minutes 2R 2R 2R 2R 1 1R
24 hours 2R 2R 2R 2R 1R 2R
48 hours 1R 1R 1R 1R 1R 1R
72 hours 1DR 1DR 1DR 1R 1DR 1DR
96 hours 1DR 1DR 1DR 1DR 1DR 0D
7 days 0DR 0DR 0DR 0DR 0DR 0D
14 days 0D 0D 0D 0D 0D 0D
Oedema
30 minutes 2 2 2 2 1 1
24 hours 2 2 2 2 1 1
48 hours 1 1 1 1 0 0
72 hours 0 1 1 0 0 0
96 hours –
14 days
All individual scores were zero
a see Attachment 1 for Draize scales.
D = desquamation (considered reversible)
R = reaction extends up to 4 cm beyond treatment site.
Mean group score
(24, 48 & 72 hour
observation):
Primary irritation index: 2.46
Erythema/Eschar Formation: 1.3
Oedema: 0.9
Comment: Very slight to well defined erythema that cleared by Day 7
and very slight to slight oedema that cleared by 96 hours.
Desquamation was also noted and persisted at all treated
sites at the Day 14 observation. This was considered to be a
reversible effect.
Result: Gulftene 16 was slight to moderately irritating to the skin of
rabbits.
FULL PUBLIC REPORT 26 April 2000
NA/713 Page 44 of 100