GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
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Draize scores:<br />
Time after Animal #<br />
treatment 1 2 3 4 5 6F<br />
Erythema/Eschar Formation<br />
30 minutes 2R 2R 2R 2R 1 1R<br />
24 hours 2R 2R 2R 2R 1R 2R<br />
48 hours 1R 1R 1R 1R 1R 1R<br />
72 hours 1DR 1DR 1DR 1R 1DR 1DR<br />
96 hours 1DR 1DR 1DR 1DR 1DR 0D<br />
7 days 0DR 0DR 0DR 0DR 0DR 0D<br />
14 days 0D 0D 0D 0D 0D 0D<br />
Oedema<br />
30 minutes 2 2 2 2 1 1<br />
24 hours 2 2 2 2 1 1<br />
48 hours 1 1 1 1 0 0<br />
72 hours 0 1 1 0 0 0<br />
96 hours –<br />
14 days<br />
All individual scores were zero<br />
a see Attachment 1 for Draize scales.<br />
D = desquamation (considered reversible)<br />
R = reaction extends up to 4 cm beyond treatment site.<br />
Mean group score<br />
(24, 48 & 72 hour<br />
observation):<br />
Primary irritation index: 2.46<br />
Erythema/Eschar Formation: 1.3<br />
Oedema: 0.9<br />
Comment: Very slight to well defined erythema that cleared by Day 7<br />
and very slight to slight oedema that cleared by 96 hours.<br />
Desquamation was also noted and persisted at all treated<br />
sites at the Day 14 observation. This was considered to be a<br />
reversible effect.<br />
Result: Gulftene 16 was slight to moderately irritating to the skin of<br />
rabbits.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 44 of 100