GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

Mean group score
(24, 48 & 72 hour
observation):
Primary irritation index: 2.79
Erythema/Eschar Formation: 1.3
Oedema: 1.1
Comment: Well defined erythema which cleared by Day 7 and slight to
moderate oedema which cleared by 96 hours. Desquamation
was noted at all treated skin sites during the study and
persisted at the Day 14 observation. This was considered
reversible.
Result: Gulftene 14 was slight to moderately irritating to the skin of
rabbits.
9.1.5.4 Acute Dermal Irritation of Gulftene 16 (Safepharm Laboratories Limited
1996)
Test substance: Gulftene 16 (1-hexadecene)
Species/strain: Rabbit/New Zealand White
Number/sex of animals: 5 males, 1 female
Observation period: 1, 24, 48, 72, 96 hours, 7 and 14 days post exposure
Method of administration: A single semi occluded application of 0.5 mL of the neat test
substance to intact skin; after 4 hours residual test substance
was removed by gentle swabbing with 74% industrial grade
methylated spirits;
A contralateral area of untreated skin served as the control
site. Control sites were similarly swabbed.
Test method: OECD TG 404
FULL PUBLIC REPORT 26 April 2000
NA/713 Page 43 of 100