GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Mean group score<br />
(24, 48 & 72 hour<br />
observation):<br />
Primary irritation index: 2.79<br />
Erythema/Eschar Formation: 1.3<br />
Oedema: 1.1<br />
Comment: Well defined erythema which cleared by Day 7 and slight to<br />
moderate oedema which cleared by 96 hours. Desquamation<br />
was noted at all treated skin sites during the study and<br />
persisted at the Day 14 observation. This was considered<br />
reversible.<br />
Result: Gulftene 14 was slight to moderately irritating to the skin of<br />
rabbits.<br />
9.1.5.4 Acute Dermal Irritation of Gulftene 16 (Safepharm Laboratories Limited<br />
1996)<br />
Test substance: Gulftene 16 (1-hexadecene)<br />
Species/strain: Rabbit/New Zealand White<br />
Number/sex of animals: 5 males, 1 female<br />
Observation period: 1, 24, 48, 72, 96 hours, 7 and 14 days post exposure<br />
Method of administration: A single semi occluded application of 0.5 mL of the neat test<br />
substance to intact skin; after 4 hours residual test substance<br />
was removed by gentle swabbing with 74% industrial grade<br />
methylated spirits;<br />
A contralateral area of untreated skin served as the control<br />
site. Control sites were similarly swabbed.<br />
Test method: OECD TG 404<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 43 of 100