GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

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R = reaction extends up to 5 cm beyond treatment site. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 42 of 100
Mean group score (24, 48 & 72 hour observation): Primary irritation index: 2.79 Erythema/Eschar Formation: 1.3 Oedema: 1.1 Comment: Well defined erythema which cleared by Day 7 and slight to moderate oedema which cleared by 96 hours. Desquamation was noted at all treated skin sites during the study and persisted at the Day 14 observation. This was considered reversible. Result: Gulftene 14 was slight to moderately irritating to the skin of rabbits. 9.1.5.4 Acute Dermal Irritation of Gulftene 16 (Safepharm Laboratories Limited 1996) Test substance: Gulftene 16 (1-hexadecene) Species/strain: Rabbit/New Zealand White Number/sex of animals: 5 males, 1 female Observation period: 1, 24, 48, 72, 96 hours, 7 and 14 days post exposure Method of administration: A single semi occluded application of 0.5 mL of the neat test substance to intact skin; after 4 hours residual test substance was removed by gentle swabbing with 74% industrial grade methylated spirits; A contralateral area of untreated skin served as the control site. Control sites were similarly swabbed. Test method: OECD TG 404 FULL PUBLIC REPORT 26 April 2000 NA/713 Page 43 of 100
Page 1 and 2: File No: NA/713 26 April 2000 NATIO
Page 3 and 4: 3. PHYSICAL AND CHEMICAL PROPERTIES
Page 5 and 6: Hydrolysis as a Function of pH: Dis
Page 7 and 8: No definitive test results for the
Page 9 and 10: 18 and are automatically discharged
Page 11 and 12: esultant oil/water emulsion is pass
Page 13 and 14: The results for a modified Sturm te
Page 15 and 16: was also performed according to the
Page 17 and 18: 9. EVALUATION OF TOXICOLOGICAL DATA
Page 19 and 20: 9.1.2 Dermal Toxicity 9.1.2.1 Rabbi
Page 21 and 22: 9.1.6.1 Rabbit/NZ White C12 - C16 A
Page 23 and 24: 9.3.1.5 Chromosome aberration Human
Page 25 and 26: Clinical observations: A few days a
Page 27 and 28: LD50: > 5 000 mg/kg Result: C20-24
Page 29 and 30: 9.1.1.7 Acute Oral Toxicity of Othe
Page 31 and 32: hair at the treatment site. Morphol
Page 33 and 34: Result: C20-24 Alkenes, branched an
Page 35 and 36: 9.1.3 Inhalation Toxicity 9.1.3.1 A
Page 37 and 38: FULL PUBLIC REPORT 26 April 2000 NA
Page 39 and 40: Draize score abraded skins: Time af
Page 41: 9.1.5.3 Acute Dermal Irritation of
Page 45 and 46: 9.1.5.5 Acute Dermal Irritation of
Page 47 and 48: Draize scores: Time after Animal #
Page 49 and 50: 9.1.5.8 Acute Dermal Irritation of
Page 51 and 52: Draize scores of non irrigated eyes
Page 53 and 54: 9.1.6.3 Acute Eye Irritation of C16
Page 55 and 56: Draize scores of irrigated eyes: Ti
Page 57 and 58: 9.1.7 Skin Sensitisation 9.1.7.1 Sk
Page 59 and 60: that sensitisation may have been in
Page 61 and 62: Number of animals: 20 test animals,
Page 63 and 64: liver parenchyma. Result: Repeated
Page 65 and 66: Pathology: F0 males and satellite f
Page 67 and 68: were observed at the end of the rec
Page 69 and 70: negative control. The positive cont
Page 71 and 72: increases in the incidence of aberr
Page 73 and 74: Clinical observations: No mortality
Page 75 and 76: hour observation and crust formatio
Page 77 and 78: 10. ASSESSMENT OF ENVIRONMENTAL EFF
Page 79 and 80: with 42% less growth (relative to t
Page 81 and 82: 10.2 TESTS ON MARINE ORGANISMS Exot
Page 83 and 84: 6.25% WAF 5 of the test animals had
Page 85 and 86: NOEL (96 h) < 0.09 g/L FULL PUBLIC
Page 87 and 88: the 48 hour NOEL was less than 1 90
Page 89 and 90: 11. ASSESSMENT OF ENVIRONMENTAL HAZ
Page 91 and 92: R65 - May Cause Lung Damage if Swal
Page 93 and 94:
14. MATERIAL SAFETY DATA SHEET The
Page 95 and 96:
Gerarde, H. (1963) Toxicological St
Page 97 and 98:
Safepharm Laboratories Limited (199
Page 99 and 100:
Wildlife International Ltd (1995) 1
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GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

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