GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

Mortality: Nil.
Morphological findings: No gross pathology at necropsy.
LD50: > 8 500 mg/m 3 mist (1 hour)
Result: C16 Alpha Olefin was of low acute inhalation toxicity in rats.
9.1.3.3 Acute Inhalation Toxicity of C16-C18 Alkene (EU 1995)
The following data is taken from the HEDSET data sheet for 1-hexadecene. The full study
report was not provided in the submission.
The HEDSET documents indicate this test was not conducted in accordance with GLP or
established testing guidelines.
Test Substance Comment LC50
C16-C18 No deaths in Sprague Dawley rats from
one or four hour exposure to saturated
vapours
9.1.4 Aspiration Toxicity (Gerarde 1963)
Test Substance: C6 - C18 alpha olefins; C19 beta olefin
Species/strain: Rat/Wistar strain, albino
Number/sex of animals: 4 or 5 males/group
FULL PUBLIC REPORT 26 April 2000
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No details given
Method of administration: 0.2 mL of test substance was placed in the mouth of rats
anaesthesised to the point of apnoea. As the animals began
to breathe the nostrils were held until the test substance had
been aspirated or the animal regained consciousness.
Test method: In house investigation
Necropsy: All alkenes tested except hexene (difficult to dose because
of volatility) were aspirated into the lungs but there was a
distinct break in mortality between C14 and C16.
From C8 to C14 all treated animals died within 24 hours. At
C16 there was no mortality. There was one mortality each
with C18 and C19. Lung weights were increased in alkene
treated animals compared to controls. The affected animals
showed acute chemical pneumonitis.
Result: There is a significant aspiration hazard with C6-C14 alkenes