GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

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9.1.2.6 Acute Dermal Toxicity of Other Alkenes The following data, unless otherwise indicated, are taken from HEDSET data sheets for 1dodecene 1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not provided in the submission. The HEDSET documents indicate these tests were not conducted in accordance with GLP or OECD or EC testing guidelines. In each case New Zealand white rabbits were administered single dermal doses of 10 000 mg/kg of test substance. Test Substance Comment LD50 C12-C14 olefin H14 - >10 000 mg/kg C12 - C26* Olefin/Paraffin H18 3/sex One animal died on Day 9 showing hyporeactivity and diarrhoea. Weight loss observed in 75% of animals. No pathology seen. C14 – C16* Olefin H16 6 animals, male and female. 24 hour exposure. C14 – C18 Olefin H16 6 animals, male and female. C14 – C18* Olefin/Paraffin H18 C14 – C26* Olefin/Paraffin H18 24 hour exposure. 3/sex. 24 hour exposure. All gained weight satisfactorily. No mortality. No pathology seen. 3/sex. 24 hour exposure. All gained weight satisfactorily. No mortality. C16-C18 H16 6 animals, male and female. 24 hour exposure. C18 – C24* Olefins H18 3/sex. All gained weight satisfactorily. C18 – C26* Olefin/Paraffin H18 C18 – C30* Olefin/Alcohol H18 No pathology seen. No mortality. 3/sex. All gained weight satisfactorily. No pathology seen. No mortality. 3/sex. All gained weight satisfactorily. No pathology seen. No mortality. * Purity not specified. H14 (EU 1995) H16 (EU 1995) H18 (EU 1995) FULL PUBLIC REPORT 26 April 2000 NA/713 Page 34 of 100 >10 000 mg/kg >10 000 mg/kg >10 000 mg/kg >10 000 mg/kg >10 000 mg/kg >10 000 mg/kg >10 000 mg/kg >10 000 mg/kg >10 000 mg/kg
9.1.3 Inhalation Toxicity 9.1.3.1 Acute Inhalation Toxicity of C12-C16 Alpha Olefin (Rinehart 1967) Test Substance: C12-C16 alpha Olefin (98.5% olefins, 1.5% saturates) Species/strain: Rat/Wistar Number/sex of animals: 10 males Observation period: 14 days Method of administration: Whole body exposure to saturated mists for one hour; exposure concentration to aerosol size of 9 900 mg/m 3 mist (1 hour) Result: C12-C16 Alpha Olefin was of low acute inhalation toxicity in rats. 9.1.3.2 Acute Inhalation Toxicity of C16 Alpha Olefin (Rinehart 1967) Test Substance: C16 alpha Olefin (98.5% olefins, 1.5% saturates) Species/strain: Rat/Wistar Number/sex of animals: 10 males Observation period: 14 days Method of administration: Whole body exposure to saturated mists for one hour; exposure concentration to aerosol size of
Page 1 and 2: File No: NA/713 26 April 2000 NATIO
Page 3 and 4: 3. PHYSICAL AND CHEMICAL PROPERTIES
Page 5 and 6: Hydrolysis as a Function of pH: Dis
Page 7 and 8: No definitive test results for the
Page 9 and 10: 18 and are automatically discharged
Page 11 and 12: esultant oil/water emulsion is pass
Page 13 and 14: The results for a modified Sturm te
Page 15 and 16: was also performed according to the
Page 17 and 18: 9. EVALUATION OF TOXICOLOGICAL DATA
Page 19 and 20: 9.1.2 Dermal Toxicity 9.1.2.1 Rabbi
Page 21 and 22: 9.1.6.1 Rabbit/NZ White C12 - C16 A
Page 23 and 24: 9.3.1.5 Chromosome aberration Human
Page 25 and 26: Clinical observations: A few days a
Page 27 and 28: LD50: > 5 000 mg/kg Result: C20-24
Page 29 and 30: 9.1.1.7 Acute Oral Toxicity of Othe
Page 31 and 32: hair at the treatment site. Morphol
Page 33: Result: C20-24 Alkenes, branched an
Page 37 and 38: FULL PUBLIC REPORT 26 April 2000 NA
Page 39 and 40: Draize score abraded skins: Time af
Page 41 and 42: 9.1.5.3 Acute Dermal Irritation of
Page 43 and 44: Mean group score (24, 48 & 72 hour
Page 47 and 48: Draize scores: Time after Animal #
Page 51 and 52: Draize scores of non irrigated eyes
Page 53 and 54: 9.1.6.3 Acute Eye Irritation of C16
Page 55 and 56: Draize scores of irrigated eyes: Ti
Page 57 and 58: 9.1.7 Skin Sensitisation 9.1.7.1 Sk
Page 59 and 60: that sensitisation may have been in
Page 61 and 62: Number of animals: 20 test animals,
Page 63 and 64: liver parenchyma. Result: Repeated
Page 65 and 66: Pathology: F0 males and satellite f
Page 67 and 68: were observed at the end of the rec
Page 69 and 70: negative control. The positive cont
Page 71 and 72: increases in the incidence of aberr
Page 73 and 74: Clinical observations: No mortality
Page 75 and 76: hour observation and crust formatio
Page 77 and 78: 10. ASSESSMENT OF ENVIRONMENTAL EFF
Page 79 and 80: with 42% less growth (relative to t
Page 81 and 82: 10.2 TESTS ON MARINE ORGANISMS Exot
Page 83 and 84: 6.25% WAF 5 of the test animals had
Page 85 and 86:
NOEL (96 h) < 0.09 g/L FULL PUBLIC
Page 87 and 88:
the 48 hour NOEL was less than 1 90
Page 89 and 90:
11. ASSESSMENT OF ENVIRONMENTAL HAZ
Page 91 and 92:
R65 - May Cause Lung Damage if Swal
Page 93 and 94:
14. MATERIAL SAFETY DATA SHEET The
Page 95 and 96:
Gerarde, H. (1963) Toxicological St
Page 97 and 98:
Safepharm Laboratories Limited (199
Page 99 and 100:
Wildlife International Ltd (1995) 1
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GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

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