GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
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9.1.2.6 Acute Dermal Toxicity of Other Alkenes<br />
The following data, unless otherwise indicated, are taken from HEDSET data sheets for 1dodecene<br />
1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not<br />
provided in the submission.<br />
The HEDSET documents indicate these tests were not conducted in accordance with GLP or<br />
OECD or EC testing guidelines.<br />
In each case New Zealand white rabbits were administered single dermal doses of 10 000<br />
mg/kg of test substance.<br />
Test Substance Comment LD50<br />
C12-C14 olefin H14 - >10 000 mg/kg<br />
C12 - C26*<br />
Olefin/Paraffin H<strong>18</strong><br />
3/sex<br />
One animal died on Day 9 showing<br />
hyporeactivity and diarrhoea. Weight loss<br />
observed in 75% of animals. No<br />
pathology seen.<br />
C14 – <strong>C16</strong>* Olefin H16 6 animals, male and female.<br />
24 hour exposure.<br />
C14 – C<strong>18</strong> Olefin H16 6 animals, male and female.<br />
C14 – C<strong>18</strong>* Olefin/Paraffin<br />
H<strong>18</strong><br />
C14 – C26*<br />
Olefin/Paraffin H<strong>18</strong><br />
24 hour exposure.<br />
3/sex. 24 hour exposure. All gained<br />
weight satisfactorily. No mortality. No<br />
pathology seen.<br />
3/sex. 24 hour exposure. All gained<br />
weight satisfactorily. No mortality.<br />
<strong>C16</strong>-C<strong>18</strong> H16 6 animals, male and female. 24 hour<br />
exposure.<br />
C<strong>18</strong> – C24* Olefins H<strong>18</strong> 3/sex. All gained weight satisfactorily.<br />
C<strong>18</strong> – C26*<br />
Olefin/Paraffin H<strong>18</strong><br />
C<strong>18</strong> – C30* Olefin/Alcohol<br />
H<strong>18</strong><br />
No pathology seen. No mortality.<br />
3/sex. All gained weight satisfactorily.<br />
No pathology seen. No mortality.<br />
3/sex. All gained weight satisfactorily.<br />
No pathology seen. No mortality.<br />
* Purity not specified. H14 (EU 1995) H16 (EU 1995) H<strong>18</strong> (EU 1995)<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 34 of 100<br />
>10 000 mg/kg<br />
>10 000 mg/kg<br />
>10 000 mg/kg<br />
>10 000 mg/kg<br />
>10 000 mg/kg<br />
>10 000 mg/kg<br />
>10 000 mg/kg<br />
>10 000 mg/kg<br />
>10 000 mg/kg