GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

9.1.2.6 Acute Dermal Toxicity of Other Alkenes
The following data, unless otherwise indicated, are taken from HEDSET data sheets for 1dodecene
1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not
provided in the submission.
The HEDSET documents indicate these tests were not conducted in accordance with GLP or
OECD or EC testing guidelines.
In each case New Zealand white rabbits were administered single dermal doses of 10 000
mg/kg of test substance.
Test Substance Comment LD50
C12-C14 olefin H14 - >10 000 mg/kg
C12 - C26*
Olefin/Paraffin H18
3/sex
One animal died on Day 9 showing
hyporeactivity and diarrhoea. Weight loss
observed in 75% of animals. No
pathology seen.
C14 – C16* Olefin H16 6 animals, male and female.
24 hour exposure.
C14 – C18 Olefin H16 6 animals, male and female.
C14 – C18* Olefin/Paraffin
H18
C14 – C26*
Olefin/Paraffin H18
24 hour exposure.
3/sex. 24 hour exposure. All gained
weight satisfactorily. No mortality. No
pathology seen.
3/sex. 24 hour exposure. All gained
weight satisfactorily. No mortality.
C16-C18 H16 6 animals, male and female. 24 hour
exposure.
C18 – C24* Olefins H18 3/sex. All gained weight satisfactorily.
C18 – C26*
Olefin/Paraffin H18
C18 – C30* Olefin/Alcohol
H18
No pathology seen. No mortality.
3/sex. All gained weight satisfactorily.
No pathology seen. No mortality.
3/sex. All gained weight satisfactorily.
No pathology seen. No mortality.
* Purity not specified. H14 (EU 1995) H16 (EU 1995) H18 (EU 1995)
FULL PUBLIC REPORT 26 April 2000
NA/713 Page 34 of 100
>10 000 mg/kg
>10 000 mg/kg
>10 000 mg/kg
>10 000 mg/kg
>10 000 mg/kg
>10 000 mg/kg
>10 000 mg/kg
>10 000 mg/kg
>10 000 mg/kg