GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
Observation period: 14 days After 24 hours residual test substance was removed with tap water. Clinical observations: 4 males and 4 females lost weight or failed to gain weight between Days 7 and 14; Slight diarrhoea in one female on Days 9 and 10. Test method: OECD TG 402 Mortality: Nil Morphological findings: No abnormalities detected at necropsy. LD50: > 2 020 mg/kg Result: C18 Isomerised Olefin was of low dermal toxicity in rats. 9.1.2.5 Acute Dermal Toxicity of C20-24 Alkenes, branched and linear (Safepharm Laboratories Limited 1998) Test Substance: C20-24 Alkenes, branched and linear Species/strain: Rat/ Sprague Dawley Crl:CD BR Number/sex of animals: 5/sex Method of administration: A single semi occluded application of 2 000 mg/kg bw (dose volume 2.52 mL/kg); After 24 hours the treated site wiped clean with cotton wool moistened with liquid paraffin. Observation period: 14 days. The treated sites were observed for evidence of dermal irritation approximately 30 minutes after bandage removal and on Days 3, 7, 10 and 14. Clinical observations: No signs of systemic toxicity noted. Test method: OECD TG 402 Mortality: Nil Dermal effects: No erythema or oedema was observed (all individual scores were zero). Morphological findings: No abnormalities detected at necropsy. LD50: > 2 000 mg/kg FULL PUBLIC REPORT 26 April 2000 NA/713 Page 32 of 100
Result: C20-24 Alkenes, branched and linear was of low dermal toxicity in rats. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 33 of 100
- Page 1 and 2: File No: NA/713 26 April 2000 NATIO
- Page 3 and 4: 3. PHYSICAL AND CHEMICAL PROPERTIES
- Page 5 and 6: Hydrolysis as a Function of pH: Dis
- Page 7 and 8: No definitive test results for the
- Page 9 and 10: 18 and are automatically discharged
- Page 11 and 12: esultant oil/water emulsion is pass
- Page 13 and 14: The results for a modified Sturm te
- Page 15 and 16: was also performed according to the
- Page 17 and 18: 9. EVALUATION OF TOXICOLOGICAL DATA
- Page 19 and 20: 9.1.2 Dermal Toxicity 9.1.2.1 Rabbi
- Page 21 and 22: 9.1.6.1 Rabbit/NZ White C12 - C16 A
- Page 23 and 24: 9.3.1.5 Chromosome aberration Human
- Page 25 and 26: Clinical observations: A few days a
- Page 27 and 28: LD50: > 5 000 mg/kg Result: C20-24
- Page 29 and 30: 9.1.1.7 Acute Oral Toxicity of Othe
- Page 31: hair at the treatment site. Morphol
- Page 35 and 36: 9.1.3 Inhalation Toxicity 9.1.3.1 A
- Page 37 and 38: FULL PUBLIC REPORT 26 April 2000 NA
- Page 39 and 40: Draize score abraded skins: Time af
- Page 41 and 42: 9.1.5.3 Acute Dermal Irritation of
- Page 43 and 44: Mean group score (24, 48 & 72 hour
- Page 45 and 46: 9.1.5.5 Acute Dermal Irritation of
- Page 47 and 48: Draize scores: Time after Animal #
- Page 49 and 50: 9.1.5.8 Acute Dermal Irritation of
- Page 51 and 52: Draize scores of non irrigated eyes
- Page 53 and 54: 9.1.6.3 Acute Eye Irritation of C16
- Page 55 and 56: Draize scores of irrigated eyes: Ti
- Page 57 and 58: 9.1.7 Skin Sensitisation 9.1.7.1 Sk
- Page 59 and 60: that sensitisation may have been in
- Page 61 and 62: Number of animals: 20 test animals,
- Page 63 and 64: liver parenchyma. Result: Repeated
- Page 65 and 66: Pathology: F0 males and satellite f
- Page 67 and 68: were observed at the end of the rec
- Page 69 and 70: negative control. The positive cont
- Page 71 and 72: increases in the incidence of aberr
- Page 73 and 74: Clinical observations: No mortality
- Page 75 and 76: hour observation and crust formatio
- Page 77 and 78: 10. ASSESSMENT OF ENVIRONMENTAL EFF
- Page 79 and 80: with 42% less growth (relative to t
- Page 81 and 82: 10.2 TESTS ON MARINE ORGANISMS Exot
Result: C20-24 Alkenes, branched and linear was of low dermal<br />
toxicity in rats.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 33 of 100
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