GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
Acute Dermal Toxicity 9.1.2.1 Acute Dermal Toxicity of C12-C16 Alpha Olefin (Rinehart 1967), 1967 #29]) Test Substance: C12-C16 Alpha Olefin (98.5% olefin,1.5% saturates) Species/strain: Rabbit/New Zealand White Number/sex of animals: 4 males Method of administration: 10 000 mg/kg (dose volume 16 mL/kg) of test substance applied to an intact and abraded area of skin and held under semi occlusive dressing for 24 hours;. Observation period: 14 days Test method: US Federal Hazardous Substances Labelling Act. Mortality: Nil. Clinical observations: Skin became very taut, dry and scaly, with no regrowth of hair at the treatment site Morphological findings: No abnormalities detected at necropsy. LD50: > 10 000 mg/kg Result: C12-C16 Alpha Olefin was of low dermal toxicity in rats. 9.1.2.2 Acute Dermal Toxicity of C16 Alpha Olefin (Rinehart 1967) Test Substance: C16 Alpha Olefin (98.5% olefin,1.5% saturates) Species/strain: Rabbit/New Zealand White Number/sex of animals: 4 males Method of administration: 10 000 mg/kg (dose volume 16 mL/kg) of test substance applied to an intact and abraded area of skin and held under semi occlusive dressing for 24 hours. Observation period: 14 days Test method: US Federal Hazardous Substances Labelling Act Mortality: One death due to broken neck Clinical observations: Skin became very taut, dry and scaly, with no regrowth of FULL PUBLIC REPORT 26 April 2000 NA/713 Page 30 of 100
hair at the treatment site. Morphological findings: No abnormalities detected at necropsy. LD50: > 10 000 mg/kg Result: C16 Alpha Olefin was of low dermal toxicity in rats. 9.1.2.3 Acute Dermal Toxicity of C16 Isomerised Olefin (Stillmeadow Inc 1993) Test Substance: C16 Isomerised Olefin Species/strain: Rabbit/New Zealand White Number/sex of animals: 5/sex Method of administration: A single semi occluded application of 2 020 mg/kg bodyweight (dose volume 2.37 mL/kg); After 24 hours residual test substance was removed with tap water. Observation period: 14 days Test method: OECD TG 402 Mortality: One male died on Day 14 after final observations were made Clinical observations: The male that died had lost weight during the study. All other animals appeared normal for the duration of the study. Morphological findings: The male that died had mottled lungs with white nodules throughout. No abnormalities detected in other animals at necropsy LD50: > 2 020 mg/kg Result: C16 Isomerised Olefin was of low dermal toxicity in rats. 9.1.2.4 Acute Dermal Toxicity of C18 Isomerised Olefin (Stillmeadow Inc 1993) Test Substance: C18 Isomerised Olefin Species/strain: Rabbit/New Zealand White Number/sex of animals: 5/sex Method of administration: A single semi occluded application of 2 020 mg/kg bodyweight (dose volume 2.35 mL/kg); FULL PUBLIC REPORT 26 April 2000 NA/713 Page 31 of 100
- Page 1 and 2: File No: NA/713 26 April 2000 NATIO
- Page 3 and 4: 3. PHYSICAL AND CHEMICAL PROPERTIES
- Page 5 and 6: Hydrolysis as a Function of pH: Dis
- Page 7 and 8: No definitive test results for the
- Page 9 and 10: 18 and are automatically discharged
- Page 11 and 12: esultant oil/water emulsion is pass
- Page 13 and 14: The results for a modified Sturm te
- Page 15 and 16: was also performed according to the
- Page 17 and 18: 9. EVALUATION OF TOXICOLOGICAL DATA
- Page 19 and 20: 9.1.2 Dermal Toxicity 9.1.2.1 Rabbi
- Page 21 and 22: 9.1.6.1 Rabbit/NZ White C12 - C16 A
- Page 23 and 24: 9.3.1.5 Chromosome aberration Human
- Page 25 and 26: Clinical observations: A few days a
- Page 27 and 28: LD50: > 5 000 mg/kg Result: C20-24
- Page 29: 9.1.1.7 Acute Oral Toxicity of Othe
- Page 33 and 34: Result: C20-24 Alkenes, branched an
- Page 35 and 36: 9.1.3 Inhalation Toxicity 9.1.3.1 A
- Page 37 and 38: FULL PUBLIC REPORT 26 April 2000 NA
- Page 39 and 40: Draize score abraded skins: Time af
- Page 41 and 42: 9.1.5.3 Acute Dermal Irritation of
- Page 43 and 44: Mean group score (24, 48 & 72 hour
- Page 45 and 46: 9.1.5.5 Acute Dermal Irritation of
- Page 47 and 48: Draize scores: Time after Animal #
- Page 49 and 50: 9.1.5.8 Acute Dermal Irritation of
- Page 51 and 52: Draize scores of non irrigated eyes
- Page 53 and 54: 9.1.6.3 Acute Eye Irritation of C16
- Page 55 and 56: Draize scores of irrigated eyes: Ti
- Page 57 and 58: 9.1.7 Skin Sensitisation 9.1.7.1 Sk
- Page 59 and 60: that sensitisation may have been in
- Page 61 and 62: Number of animals: 20 test animals,
- Page 63 and 64: liver parenchyma. Result: Repeated
- Page 65 and 66: Pathology: F0 males and satellite f
- Page 67 and 68: were observed at the end of the rec
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- Page 71 and 72: increases in the incidence of aberr
- Page 73 and 74: Clinical observations: No mortality
- Page 75 and 76: hour observation and crust formatio
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Acute Dermal Toxicity<br />
9.1.2.1 Acute Dermal Toxicity of C12-<strong>C16</strong> Alpha Olefin (Rinehart 1967), 1967<br />
#29])<br />
Test Substance: C12-<strong>C16</strong> Alpha Olefin (98.5% olefin,1.5% saturates)<br />
Species/strain: Rabbit/New Zealand White<br />
Number/sex of animals: 4 males<br />
Method of administration: 10 000 mg/kg (dose volume 16 mL/kg) of test substance<br />
applied to an intact and abraded area of skin and held under<br />
semi occlusive dressing for 24 hours;.<br />
Observation period: 14 days<br />
Test method: US Federal Hazardous Substances Labelling Act.<br />
Mortality: Nil.<br />
Clinical observations: Skin became very taut, dry and scaly, with no regrowth of<br />
hair at the treatment site<br />
Morphological findings: No abnormalities detected at necropsy.<br />
LD50: > 10 000 mg/kg<br />
Result: C12-<strong>C16</strong> Alpha Olefin was of low dermal toxicity in rats.<br />
9.1.2.2 Acute Dermal Toxicity of <strong>C16</strong> Alpha Olefin (Rinehart 1967)<br />
Test Substance: <strong>C16</strong> Alpha Olefin (98.5% olefin,1.5% saturates)<br />
Species/strain: Rabbit/New Zealand White<br />
Number/sex of animals: 4 males<br />
Method of administration: 10 000 mg/kg (dose volume 16 mL/kg) of test substance<br />
applied to an intact and abraded area of skin and held under<br />
semi occlusive dressing for 24 hours.<br />
Observation period: 14 days<br />
Test method: US Federal Hazardous Substances Labelling Act<br />
Mortality: One death due to broken neck<br />
Clinical observations: Skin became very taut, dry and scaly, with no regrowth of<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 30 of 100
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