GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
FULL PUBLIC REPORT 26 April 2000 NA/713 Page 28 of 100
9.1.1.7 Acute Oral Toxicity of Other Alkenes The following data, unless otherwise indicated, are taken from HEDSET data sheets for 1dodecene 1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not provided in the submission. The HEDSET documents indicate these tests were not conducted in accordance with GLP or OECD or EC testing guidelines. In each case rats were administered single oral doses of 10 g/kg of test substance. Test Substance Comment LD50 C12 - C14 olefin H14 - >10 000 mg/kg C12 - C26* Olefin/Paraffin H18 10 CFE rats, 5 males, 5 females. Animals appeared hyporeactive. All but one animal had good weight gain. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 29 of 100 >10 000 mg/kg C14-C16 olefin H14 - >10 000 mg/kg C14 – C18* Olefin/Paraffin H18 C14 – C26* Olefin/Paraffin H18 10 CFE rats, 5 males, 5 females. All gained weight satisfactorily. 10 CFE rats, 5 males, 5 females. All gained weight satisfactorily. >10 000 mg/kg >10 000 mg/kg C16-C18 olefin H16 - > 10 000 mg/kg C18 – C24* Olefins H18 All gained weight satisfactorily. >10 000 mg/kg C18 – C26* Olefin/Paraffin H18 C18 – C30* Olefin/Alcohol H18 * Purity not specified. H14 – (EU 1995). H16 – (EU 1995) H18 – (EU 1995) 10 CFE rats, 5 males, 5 females. All gained weight satisfactorily. 10 CFE rats, 5 males, 5 females. All gained weight satisfactorily. Slight hyporeactivity was seen. >10 000 mg/kg >10 000 mg/kg
- Page 1 and 2: File No: NA/713 26 April 2000 NATIO
- Page 3 and 4: 3. PHYSICAL AND CHEMICAL PROPERTIES
- Page 5 and 6: Hydrolysis as a Function of pH: Dis
- Page 7 and 8: No definitive test results for the
- Page 9 and 10: 18 and are automatically discharged
- Page 11 and 12: esultant oil/water emulsion is pass
- Page 13 and 14: The results for a modified Sturm te
- Page 15 and 16: was also performed according to the
- Page 17 and 18: 9. EVALUATION OF TOXICOLOGICAL DATA
- Page 19 and 20: 9.1.2 Dermal Toxicity 9.1.2.1 Rabbi
- Page 21 and 22: 9.1.6.1 Rabbit/NZ White C12 - C16 A
- Page 23 and 24: 9.3.1.5 Chromosome aberration Human
- Page 25 and 26: Clinical observations: A few days a
- Page 27: LD50: > 5 000 mg/kg Result: C20-24
- Page 31 and 32: hair at the treatment site. Morphol
- Page 33 and 34: Result: C20-24 Alkenes, branched an
- Page 35 and 36: 9.1.3 Inhalation Toxicity 9.1.3.1 A
- Page 37 and 38: FULL PUBLIC REPORT 26 April 2000 NA
- Page 39 and 40: Draize score abraded skins: Time af
- Page 41 and 42: 9.1.5.3 Acute Dermal Irritation of
- Page 43 and 44: Mean group score (24, 48 & 72 hour
- Page 45 and 46: 9.1.5.5 Acute Dermal Irritation of
- Page 47 and 48: Draize scores: Time after Animal #
- Page 49 and 50: 9.1.5.8 Acute Dermal Irritation of
- Page 51 and 52: Draize scores of non irrigated eyes
- Page 53 and 54: 9.1.6.3 Acute Eye Irritation of C16
- Page 55 and 56: Draize scores of irrigated eyes: Ti
- Page 57 and 58: 9.1.7 Skin Sensitisation 9.1.7.1 Sk
- Page 59 and 60: that sensitisation may have been in
- Page 61 and 62: Number of animals: 20 test animals,
- Page 63 and 64: liver parenchyma. Result: Repeated
- Page 65 and 66: Pathology: F0 males and satellite f
- Page 67 and 68: were observed at the end of the rec
- Page 69 and 70: negative control. The positive cont
- Page 71 and 72: increases in the incidence of aberr
- Page 73 and 74: Clinical observations: No mortality
- Page 75 and 76: hour observation and crust formatio
- Page 77 and 78: 10. ASSESSMENT OF ENVIRONMENTAL EFF
9.1.1.7 Acute Oral Toxicity of Other Alkenes<br />
The following data, unless otherwise indicated, are taken from HEDSET data sheets for 1dodecene<br />
1-tetradecene 1-hexadecene and 1-octadecene. The full study reports were not<br />
provided in the submission.<br />
The HEDSET documents indicate these tests were not conducted in accordance with GLP or<br />
OECD or EC testing guidelines.<br />
In each case rats were administered single oral doses of 10 g/kg of test substance.<br />
Test Substance Comment LD50<br />
C12 - C14 olefin H14 - >10 000 mg/kg<br />
C12 - C26*<br />
Olefin/Paraffin H<strong>18</strong><br />
10 CFE rats, 5 males, 5 females.<br />
Animals appeared hyporeactive.<br />
All but one animal had good weight gain.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 29 of 100<br />
>10 000 mg/kg<br />
C14-<strong>C16</strong> olefin H14 - >10 000 mg/kg<br />
C14 – C<strong>18</strong>*<br />
Olefin/Paraffin H<strong>18</strong><br />
C14 – C26*<br />
Olefin/Paraffin H<strong>18</strong><br />
10 CFE rats, 5 males, 5 females.<br />
All gained weight satisfactorily.<br />
10 CFE rats, 5 males, 5 females.<br />
All gained weight satisfactorily.<br />
>10 000 mg/kg<br />
>10 000 mg/kg<br />
<strong>C16</strong>-C<strong>18</strong> olefin H16 - > 10 000 mg/kg<br />
C<strong>18</strong> – C24* Olefins H<strong>18</strong> All gained weight satisfactorily. >10 000 mg/kg<br />
C<strong>18</strong> – C26*<br />
Olefin/Paraffin H<strong>18</strong><br />
C<strong>18</strong> – C30*<br />
Olefin/Alcohol H<strong>18</strong><br />
* Purity not specified.<br />
H14 – (EU 1995).<br />
H16 – (EU 1995)<br />
H<strong>18</strong> – (EU 1995)<br />
10 CFE rats, 5 males, 5 females.<br />
All gained weight satisfactorily.<br />
10 CFE rats, 5 males, 5 females.<br />
All gained weight satisfactorily.<br />
Slight hyporeactivity was seen.<br />
>10 000 mg/kg<br />
>10 000 mg/kg
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