GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

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9.1.1.4 Acute Oral Toxicity of C18 Isomerised Olefin (Stillmeadow Inc 1993) Test Substance: C18 Isomerised Olefin Species/strain: Rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Oral, (gavage) 5 050 mg/kg (dose volume of 5.92 mL/kg) Test method: OECD TG 420 – fixed dose method Clinical observations: In life observations of note included diarrhoea, piloerection and polyuria, which were no longer evident by Day 11. Mortality: Nil Morphological findings: No abnormalities detected. LD50: > 5 050 mg/kg Result: C18 Isomerised Olefin was of very low acute oral toxicity in rats. 9.1.1.5 Acute Oral Toxicity of C20-24 Alkenes, branched and linear (Safepharm Laboratories Limited 1998) Test Substance: C20-24 Alkenes, branched and linear Species/strain: Rat/Sprague Dawley Crl:CD BR Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Oral, gavage 5 000 mg/kg (dose volume of 6.29 mL/kg) Test method: OECD TG 420 – fixed dose method Clinical observations: Hunched posture and piloerection in all animals on day of dosing; Mortality: One female found dead one day after dosing Morphological findings: The female found dead had haemorrhagic lungs, dark liver and dark kidneys; No abnormalities detected at terminal kill. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 26 of 100
LD50: > 5 000 mg/kg Result: C20-24 Alkenes, branched and linear was of very low acute oral toxicity in rats. 9.1.1.6 Acute Neurotoxicity of Gulftene 16 (Bushy Run Research Center 1992) Test substance: Gulftene 16 (1-hexadecene) Test substance purity, %: 1-hexadecene >93; 2-ethyl-1-tetradecene 2.0; 2-butyl-1dodecene 2.0; 2-hexyl-1-decene 2.0; n-hexadecene 10 000 mg/kg Result: Gulftene 16 did not appear to produce primary neurotoxicant effects. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 27 of 100
Page 1 and 2: File No: NA/713 26 April 2000 NATIO
Page 3 and 4: 3. PHYSICAL AND CHEMICAL PROPERTIES
Page 5 and 6: Hydrolysis as a Function of pH: Dis
Page 7 and 8: No definitive test results for the
Page 9 and 10: 18 and are automatically discharged
Page 11 and 12: esultant oil/water emulsion is pass
Page 13 and 14: The results for a modified Sturm te
Page 15 and 16: was also performed according to the
Page 17 and 18: 9. EVALUATION OF TOXICOLOGICAL DATA
Page 19 and 20: 9.1.2 Dermal Toxicity 9.1.2.1 Rabbi
Page 21 and 22: 9.1.6.1 Rabbit/NZ White C12 - C16 A
Page 23 and 24: 9.3.1.5 Chromosome aberration Human
Page 25: Clinical observations: A few days a
Page 29 and 30: 9.1.1.7 Acute Oral Toxicity of Othe
Page 31 and 32: hair at the treatment site. Morphol
Page 33 and 34: Result: C20-24 Alkenes, branched an
Page 35 and 36: 9.1.3 Inhalation Toxicity 9.1.3.1 A
Page 37 and 38: FULL PUBLIC REPORT 26 April 2000 NA
Page 39 and 40: Draize score abraded skins: Time af
Page 41 and 42: 9.1.5.3 Acute Dermal Irritation of
Page 43 and 44: Mean group score (24, 48 & 72 hour
Page 47 and 48: Draize scores: Time after Animal #
Page 51 and 52: Draize scores of non irrigated eyes
Page 53 and 54: 9.1.6.3 Acute Eye Irritation of C16
Page 55 and 56: Draize scores of irrigated eyes: Ti
Page 57 and 58: 9.1.7 Skin Sensitisation 9.1.7.1 Sk
Page 59 and 60: that sensitisation may have been in
Page 61 and 62: Number of animals: 20 test animals,
Page 63 and 64: liver parenchyma. Result: Repeated
Page 65 and 66: Pathology: F0 males and satellite f
Page 67 and 68: were observed at the end of the rec
Page 69 and 70: negative control. The positive cont
Page 71 and 72: increases in the incidence of aberr
Page 73 and 74: Clinical observations: No mortality
Page 75 and 76: hour observation and crust formatio
Page 77 and 78:
10. ASSESSMENT OF ENVIRONMENTAL EFF
Page 79 and 80:
with 42% less growth (relative to t
Page 81 and 82:
10.2 TESTS ON MARINE ORGANISMS Exot
Page 83 and 84:
6.25% WAF 5 of the test animals had
Page 85 and 86:
NOEL (96 h) < 0.09 g/L FULL PUBLIC
Page 87 and 88:
the 48 hour NOEL was less than 1 90
Page 89 and 90:
11. ASSESSMENT OF ENVIRONMENTAL HAZ
Page 91 and 92:
R65 - May Cause Lung Damage if Swal
Page 93 and 94:
14. MATERIAL SAFETY DATA SHEET The
Page 95 and 96:
Gerarde, H. (1963) Toxicological St
Page 97 and 98:
Safepharm Laboratories Limited (199
Page 99 and 100:
Wildlife International Ltd (1995) 1
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GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS

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