GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
9.1.1.4 Acute Oral Toxicity of C18 Isomerised Olefin (Stillmeadow Inc 1993) Test Substance: C18 Isomerised Olefin Species/strain: Rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Oral, (gavage) 5 050 mg/kg (dose volume of 5.92 mL/kg) Test method: OECD TG 420 – fixed dose method Clinical observations: In life observations of note included diarrhoea, piloerection and polyuria, which were no longer evident by Day 11. Mortality: Nil Morphological findings: No abnormalities detected. LD50: > 5 050 mg/kg Result: C18 Isomerised Olefin was of very low acute oral toxicity in rats. 9.1.1.5 Acute Oral Toxicity of C20-24 Alkenes, branched and linear (Safepharm Laboratories Limited 1998) Test Substance: C20-24 Alkenes, branched and linear Species/strain: Rat/Sprague Dawley Crl:CD BR Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Oral, gavage 5 000 mg/kg (dose volume of 6.29 mL/kg) Test method: OECD TG 420 – fixed dose method Clinical observations: Hunched posture and piloerection in all animals on day of dosing; Mortality: One female found dead one day after dosing Morphological findings: The female found dead had haemorrhagic lungs, dark liver and dark kidneys; No abnormalities detected at terminal kill. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 26 of 100
LD50: > 5 000 mg/kg Result: C20-24 Alkenes, branched and linear was of very low acute oral toxicity in rats. 9.1.1.6 Acute Neurotoxicity of Gulftene 16 (Bushy Run Research Center 1992) Test substance: Gulftene 16 (1-hexadecene) Test substance purity, %: 1-hexadecene >93; 2-ethyl-1-tetradecene 2.0; 2-butyl-1dodecene 2.0; 2-hexyl-1-decene 2.0; n-hexadecene 10 000 mg/kg Result: Gulftene 16 did not appear to produce primary neurotoxicant effects. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 27 of 100
- Page 1 and 2: File No: NA/713 26 April 2000 NATIO
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- Page 19 and 20: 9.1.2 Dermal Toxicity 9.1.2.1 Rabbi
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- Page 61 and 62: Number of animals: 20 test animals,
- Page 63 and 64: liver parenchyma. Result: Repeated
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9.1.1.4 Acute Oral Toxicity of C<strong>18</strong> Isomerised Olefin (Stillmeadow Inc 1993)<br />
Test Substance: C<strong>18</strong> Isomerised Olefin<br />
Species/strain: Rat/Sprague Dawley<br />
Number/sex of animals: 5/sex<br />
Observation period: 14 days<br />
Method of administration: Oral, (gavage) 5 050 mg/kg (dose volume of 5.92 mL/kg)<br />
Test method: OECD TG 420 – fixed dose method<br />
Clinical observations: In life observations of note included diarrhoea, piloerection<br />
and polyuria, which were no longer evident by Day 11.<br />
Mortality: Nil<br />
Morphological findings: No abnormalities detected.<br />
LD50: > 5 050 mg/kg<br />
Result: C<strong>18</strong> Isomerised Olefin was of very low acute oral toxicity in<br />
rats.<br />
9.1.1.5 Acute Oral Toxicity of C20-24 Alkenes, branched and linear (Safepharm<br />
Laboratories Limited 1998)<br />
Test Substance: C20-24 Alkenes, branched and linear<br />
Species/strain: Rat/Sprague Dawley Crl:CD BR<br />
Number/sex of animals: 5/sex<br />
Observation period: 14 days<br />
Method of administration: Oral, gavage 5 000 mg/kg (dose volume of 6.29 mL/kg)<br />
Test method: OECD TG 420 – fixed dose method<br />
Clinical observations: Hunched posture and piloerection in all animals on day of<br />
dosing;<br />
Mortality: One female found dead one day after dosing<br />
Morphological findings: The female found dead had haemorrhagic lungs, dark liver<br />
and dark kidneys;<br />
No abnormalities detected at terminal kill.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 26 of 100
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