GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
9.1 Acute Toxicity 9.1.1 Acute Oral Toxicity 9.1.1.1 Acute Oral Toxicity of C12-C16 Alpha Olefin (Rinehart 1967) Test Substance: C12-C16 alpha Olefin (98.5% olefins, 1.5% saturates) Species/strain: Rat/Wistar Number/sex of animals: 10 males Observation period: 14 days Method of administration: Gavage 5 000 mg/kg or 10 000 mg/kg (dose volume of 2.65 – 3.50 mL/kg). Test method: US Federal Hazardous Substances Labelling Act Clinical observations: A few days after dosing, animals had very coarse oily fur over the whole body, particularly severe in the hindquarter area. This observation persisted for the remainder of the observation period. Mortality: Two deaths observed in the 10 000 mg/kg dose; considered to be due to pneumonia. Morphological findings: Not reported LD50: > 5 000 mg/kg Result: C12-C16 Alpha Olefin was of very low acute oral toxicity in rats. 9.1.1.2 Acute Oral Toxicity of C16 Alpha Olefin (Rinehart 1967) Test Substance: C16 alpha Olefin (98.5% olefins, 1.5% saturates) Species/strain: Rat/Wistar Number/sex of animals: 10 males Observation period: 14 days Method of administration: Oral, gavage 5 000 mg/kg or 10 000 mg/kg (dose volume of 2.65 – 3.50 mL/kg). Test method: US Federal Hazardous Substances Labelling Act. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 24 of 100
Clinical observations: A few days after dosing, animals had very coarse oily fur over the whole body, particularly severe in the hindquarter area; Animals developed a weakness in the hindquarters which caused them to drag around the cage. This observation persisted for the remainder of the observation period. Mortality: Nil Morphological findings: Not reported. LD50: > 5 000 mg/kg Result: C16 Alpha Olefin was of very low acute oral toxicity in rats. 9.1.1.3 Acute Oral Toxicity of C16 Isomerised Olefin (Hill Top Biolabs Inc 1993) Test Substance: C16 Isomerised Olefin Species/strain: Rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: Oral, gavage 5 050 mg/kg (dose volume of 5.92 mL/kg) Test method: OECD TG 420 – fixed dose method Clinical observations: One female lost weight between Days 0 and 7 and one female failed to gain weight between days 7 and 14. Prominent in life observations included activity decrease piloerection and polyuria, which were no longer evident by Day 7. Alopecia was observed in all animals on Days 7 through 14. Mortality: Nil Morphological findings: No abnormalities detected. LD50: > 5 050 mg/kg Result: C16 Isomerised Olefin was of very low acute oral toxicity in rats. FULL PUBLIC REPORT 26 April 2000 NA/713 Page 25 of 100
- Page 1 and 2: File No: NA/713 26 April 2000 NATIO
- Page 3 and 4: 3. PHYSICAL AND CHEMICAL PROPERTIES
- Page 5 and 6: Hydrolysis as a Function of pH: Dis
- Page 7 and 8: No definitive test results for the
- Page 9 and 10: 18 and are automatically discharged
- Page 11 and 12: esultant oil/water emulsion is pass
- Page 13 and 14: The results for a modified Sturm te
- Page 15 and 16: was also performed according to the
- Page 17 and 18: 9. EVALUATION OF TOXICOLOGICAL DATA
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- Page 21 and 22: 9.1.6.1 Rabbit/NZ White C12 - C16 A
- Page 23: 9.3.1.5 Chromosome aberration Human
- Page 27 and 28: LD50: > 5 000 mg/kg Result: C20-24
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- Page 31 and 32: hair at the treatment site. Morphol
- Page 33 and 34: Result: C20-24 Alkenes, branched an
- Page 35 and 36: 9.1.3 Inhalation Toxicity 9.1.3.1 A
- Page 37 and 38: FULL PUBLIC REPORT 26 April 2000 NA
- Page 39 and 40: Draize score abraded skins: Time af
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- Page 43 and 44: Mean group score (24, 48 & 72 hour
- Page 45 and 46: 9.1.5.5 Acute Dermal Irritation of
- Page 47 and 48: Draize scores: Time after Animal #
- Page 49 and 50: 9.1.5.8 Acute Dermal Irritation of
- Page 51 and 52: Draize scores of non irrigated eyes
- Page 53 and 54: 9.1.6.3 Acute Eye Irritation of C16
- Page 55 and 56: Draize scores of irrigated eyes: Ti
- Page 57 and 58: 9.1.7 Skin Sensitisation 9.1.7.1 Sk
- Page 59 and 60: that sensitisation may have been in
- Page 61 and 62: Number of animals: 20 test animals,
- Page 63 and 64: liver parenchyma. Result: Repeated
- Page 65 and 66: Pathology: F0 males and satellite f
- Page 67 and 68: were observed at the end of the rec
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9.1 Acute Toxicity<br />
9.1.1 Acute Oral Toxicity<br />
9.1.1.1 Acute Oral Toxicity of C12-<strong>C16</strong> Alpha Olefin (Rinehart 1967)<br />
Test Substance: C12-<strong>C16</strong> alpha Olefin (98.5% olefins, 1.5% saturates)<br />
Species/strain: Rat/Wistar<br />
Number/sex of animals: 10 males<br />
Observation period: 14 days<br />
Method of administration: Gavage 5 000 mg/kg or 10 000 mg/kg (dose volume of 2.65<br />
– 3.50 mL/kg).<br />
Test method: US Federal Hazardous Substances Labelling Act<br />
Clinical observations: A few days after dosing, animals had very coarse oily fur<br />
over the whole body, particularly severe in the hindquarter<br />
area. This observation persisted for the remainder of the<br />
observation period.<br />
Mortality: Two deaths observed in the 10 000 mg/kg dose; considered<br />
to be due to pneumonia.<br />
Morphological findings: Not reported<br />
LD50: > 5 000 mg/kg<br />
Result: C12-<strong>C16</strong> Alpha Olefin was of very low acute oral toxicity in<br />
rats.<br />
9.1.1.2 Acute Oral Toxicity of <strong>C16</strong> Alpha Olefin (Rinehart 1967)<br />
Test Substance: <strong>C16</strong> alpha Olefin (98.5% olefins, 1.5% saturates)<br />
Species/strain: Rat/Wistar<br />
Number/sex of animals: 10 males<br />
Observation period: 14 days<br />
Method of administration: Oral, gavage 5 000 mg/kg or 10 000 mg/kg (dose volume of<br />
2.65 – 3.50 mL/kg).<br />
Test method: US Federal Hazardous Substances Labelling Act.<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 24 of 100
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