GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
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9.1.7.5 Other Alkenes<br />
Repeated Patch Insult<br />
Test<br />
Human Neodene <strong>18</strong> Alpha Olefin<br />
(1-octadecene)<br />
Non sensitising<br />
9.2 Repeat Dose Toxicity<br />
9.2.1 2-week, dermal Rat/Fischer 344 Gulftene 12-16 NOAEL = 1 000 mg/kg<br />
9.2.2 Other Alkenes<br />
4-week, dermal Rabbit/NZ White <strong>C16</strong> - C<strong>18</strong> Slight hyperemia,<br />
9.2.3 Up to 51 days, oral Rat/ Sprague Dawley<br />
Crl:CD BR VAF/Plus<br />
1-tetradecene (blend from three<br />
suppliers)<br />
9.2.4 13-week, oral Rat/ Crl:CD BR C20 - C24 Alkenes, Branched and<br />
Linear<br />
exfoliation, oedema<br />
NOAEL = 1 000<br />
mg/kg/day for<br />
reproductive neurotoxic<br />
effects;<br />
NOAEL = 100<br />
mg/kg/day for systemic<br />
effects in females.<br />
No NOAEL for males<br />
NOAEL = 500<br />
mg/kg/day<br />
9.3 Genetic Toxicity<br />
9.3.1 in vitro<br />
9.3.1.1 Bacterial reverse S.typhimurium, E.coli C20 - C24 Alkenes, branched and linear Negative with & w’out<br />
mutation assay<br />
activation<br />
9.3.1.2 Unscheduled DNA Rat hepatocyte primary Gulftene 12 – 16 Negative<br />
Synthesis<br />
culture<br />
9.3.1.3 BALB/3T3<br />
Mouse embryo cells Gulftene 12 – 16 Negative<br />
Transformation Test BALB/3T3-A31-1-1<br />
9.3.1.4 HGPRT Assay Chinese Hamster Ovary Gulftene 12 – 16 Negative with & w’out<br />
cell<br />
activation<br />
FULL PUBLIC REPORT<br />
26 April 2000<br />
NA/713 Page 22 of 100
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