GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS GULFTENE C16-18 ISOMERISED OLEFINS - NICNAS
The Draize Scale for evaluation of skin reactions is as follows: FULL PUBLIC REPORT 26 April 2000 NA/713 Page 100 of 100 Attachment 1 Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) 1 Very slight oedema (barely perceptible) 1 Well-defined erythema 2 Slight oedema (edges of area well-defined by definite raising 2 Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm and extending beyond area of exposure) 4 The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible Easily visible translucent areas, details of iris slightly obscure Opalescent areas, no details of iris visible size of pupil barely discernible 1 slight 25% to 50% 2 2 mild 50% to 75% 3 3 moderate Opaque iris invisible 4 severe Greater than 75% 4 CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal Vessels definitely injected above normal More diffuse deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids halfclosed Swelling with lids halfclosed to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage gross destruction 2 severe 0 none 1 slight 2 mod. 3 severe
- Page 49 and 50: 9.1.5.8 Acute Dermal Irritation of
- Page 51 and 52: Draize scores of non irrigated eyes
- Page 53 and 54: 9.1.6.3 Acute Eye Irritation of C16
- Page 55 and 56: Draize scores of irrigated eyes: Ti
- Page 57 and 58: 9.1.7 Skin Sensitisation 9.1.7.1 Sk
- Page 59 and 60: that sensitisation may have been in
- Page 61 and 62: Number of animals: 20 test animals,
- Page 63 and 64: liver parenchyma. Result: Repeated
- Page 65 and 66: Pathology: F0 males and satellite f
- Page 67 and 68: were observed at the end of the rec
- Page 69 and 70: negative control. The positive cont
- Page 71 and 72: increases in the incidence of aberr
- Page 73 and 74: Clinical observations: No mortality
- Page 75 and 76: hour observation and crust formatio
- Page 77 and 78: 10. ASSESSMENT OF ENVIRONMENTAL EFF
- Page 79 and 80: with 42% less growth (relative to t
- Page 81 and 82: 10.2 TESTS ON MARINE ORGANISMS Exot
- Page 83 and 84: 6.25% WAF 5 of the test animals had
- Page 85 and 86: NOEL (96 h) < 0.09 g/L FULL PUBLIC
- Page 87 and 88: the 48 hour NOEL was less than 1 90
- Page 89 and 90: 11. ASSESSMENT OF ENVIRONMENTAL HAZ
- Page 91 and 92: R65 - May Cause Lung Damage if Swal
- Page 93 and 94: 14. MATERIAL SAFETY DATA SHEET The
- Page 95 and 96: Gerarde, H. (1963) Toxicological St
- Page 97 and 98: Safepharm Laboratories Limited (199
- Page 99: Wildlife International Ltd (1995) 1
The Draize Scale for evaluation of skin reactions is as follows:<br />
FULL PUBLIC REPORT 26 April 2000<br />
NA/713 Page 100 of 100<br />
Attachment 1<br />
Erythema Formation Rating Oedema Formation Rating<br />
No erythema 0 No oedema 0<br />
Very slight erythema (barely perceptible) 1 Very slight oedema (barely perceptible) 1<br />
Well-defined erythema 2 Slight oedema (edges of area well-defined<br />
by definite raising<br />
2<br />
Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3<br />
Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm<br />
and extending beyond area of exposure)<br />
4<br />
The Draize scale for evaluation of eye reactions is as follows:<br />
CORNEA<br />
Opacity Rating Area of Cornea involved Rating<br />
No opacity 0 none 25% or less (not zero) 1<br />
Diffuse area, details of iris clearly<br />
visible<br />
Easily visible translucent areas, details<br />
of iris slightly obscure<br />
Opalescent areas, no details of iris<br />
visible size of pupil barely discernible<br />
1 slight 25% to 50% 2<br />
2 mild 50% to 75% 3<br />
3<br />
moderate<br />
Opaque iris invisible 4 severe<br />
Greater than 75% 4<br />
CONJUNCTIVAE<br />
Redness Rating Chemosis Rating Discharge Rating<br />
Vessels normal<br />
Vessels definitely<br />
injected above normal<br />
More diffuse deeper<br />
crimson red with<br />
individual vessels not<br />
easily discernible<br />
Diffuse beefy red<br />
0 none<br />
1<br />
slight<br />
2 mod.<br />
3 severe<br />
No swelling<br />
Any swelling above<br />
normal<br />
Obvious swelling with<br />
partial eversion of lids<br />
Swelling with lids halfclosed<br />
Swelling with lids halfclosed<br />
to completely<br />
closed<br />
0 none<br />
1 slight<br />
2 mild<br />
3 mod.<br />
4 severe<br />
No discharge<br />
Any amount different<br />
from normal<br />
Discharge with<br />
moistening of lids and<br />
adjacent hairs<br />
Discharge with<br />
moistening of lids and<br />
hairs and considerable<br />
area around eye<br />
IRIS<br />
Values Rating<br />
Normal 0 none<br />
Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight<br />
No reaction to light, haemorrhage gross destruction 2 severe<br />
0 none<br />
1 slight<br />
2 mod.<br />
3 severe
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