CHEMOMETRICS ASSISTED UV-SPECTROPHOTOMETRIC ...

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Component analyzed benzoic acid salicylic acid Table19. Statistical analysis of the results obtained for laboratory prepared and commercial dosage forms of whitefield by the proposed methods using percentage found at 40 µg/ml for benzoic acid and 20 µg/ml for salicylic acid. SP* Reported (official) methods 1 D(zero-crossing) Lab prepaed whitefield 1 D (derivative ratio) Lab prepaed whitefield 63 CLS Lab prepaed whitefield PCR Lab prepaed whitefield X 101.8 100.9 100.2 99.1 100.4 89.0 107.4 99.1 100.9 ± S 1.7 2.9 1.3 2.1 3.1 2.1 10 1.9 1.8 n 3 3 3 3 3 3 3 3 3 S 2 2.89 8.41 1.69 4.41 9.61 4.41 100 3.61 3.24 t - 0.95 1.38 1.32 0.61 7.76 7.11 1.77 0.61 F - 2.91 1.00 2.52 3.32 4.41 34.6 1.25 1.12 99.8 101.4 99.3 101.5 99.1 99.1 100.5 100.8 98.2 ± S 1.8 0.9 0.5 0.5 2.0 3.4 2.8 1.8 1.2 n 3 3 3 3 3 3 3 3 3 S 2 3.24 0.81 0.25 0.25 4.00 11.56 7.84 1.56 1.44 t - 1.68 0.63 2.15 0.44 0.28 0.33 0.61 1.44 F - 4.00 12.96 1.12 1.24 3.57 2.42 1.00 2.25 *statistical parameters Theoretical values at 95 % confidence limit are t =2.776, and F =19 % (n1 =3 , n2=3) X = mean n = number of observations S = Relative Standard deviation S 2 = variance
Com pone nt anal yzed SP * Table 20. Statistical analyses of the results obtained for laboratory prepared and commercial dosage forms of luna soap and dorin emulsion (an intra-comparison) between the proposed CLS, PCR, and derivative methods found at dosage form concentrations. 1 D(zero-crossing) prepaed Dosage form Luna soap Dorin emulsion Luna soap Lab Dorin emulsion 1 D (derivative ratio) Lab prepaed Dosage form Luna soap Dorin emulsion Luna soap Dorin emulsion 64 Lab prepaed Luna soap Dorin emuls ion CLS Dosage form Luna soap Dorin emulsio n Lab prepaed Luna soap Dorin emulsio n PCR Dosage form salic X 128.1 118.3 109. 130.2 103.9 98.6 100.9 101. 101.5 99. 104.5 102. 101 102. 101.4 99.3 ylic 7 2 7 5 .8 0 acid S 0.5 0.1 0.3 12.8 1.9 0.2 1.7 1.1 1.0 3.3 1.8 2.0 1.6 2.1 1.8 1.8 reso cinol X 113.5 120.1 64.4 91.1 101.9 99.4 98.1 100. 101.4 99. 101.4 99.6 98. 2 5 6 S 1.3 3.6 3.4 4.3 1.4 1.5 2.1 0.6 2.1 3.2 0.4 0.6 101 .7 *statistical parameters Theoretical values at 95 % confidence limit are X = mean, S = Relative standard deviation Luna soap Dorin emulsio 98.3 101.7 101. 1 1.8 1.8 1.2 n
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ADDIS ABABA UNIVERSITY SCHOOL OF GR
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ADDIS ABABA UNIVERSITY SCHOOL OF GR
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ACKNOWLEDGEMENTS Above all, my pric
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3.4.2. Preparation of samples......
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LIST OF TABLES Table 1. Spectral an
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LIST OF FIGURES Fig.1. How chemomet
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ABSTRACT Chemometrics-assisted spec
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Chemometric is the chemical discipl
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Y = a+bx.................. [2] wher
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from large sets of data. Using mult
Page 21 and 22:
Solving the equations for the K mat
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• Calibrations are generally more
Page 25 and 26: The advent of rapid, in expensive c
Page 27 and 28: The derivative spectra are always m
Page 29 and 30: The method is based on the use of t
Page 31 and 32: 2. OBJECTIVES 2.1. General objectiv
Page 33 and 34: 3.4.2. Preparation of samples A. Wh
Page 35 and 36: drug (see the discussion section).
Page 37 and 38: 3 2.5 2 1.5 1 0.5 0 200 215 230 245
Page 39 and 40: Concentration (µg/ml) Fig.15. The
Page 41 and 42: Fig.20. Box plot for pure resorcino
Page 43 and 44: It is obvious from the figures that
Page 45 and 46: From the calculated degree of overl
Page 47 and 48: Compound λ* (nm) Table 1. Spectral
Page 49 and 50: Table 3. Actual and predicted amoun
Page 51 and 52: Compound λ * (nm) Salicylic acid R
Page 53 and 54: Table 6. Actual and predicted amoun
Page 55 and 56: The ratio spectra thus obtained are
Page 57 and 58: 0.1 0.0 0.0 0.0 -0.0 -0.0 -0.1 -0.1
Page 59 and 60: Table.8. Actual and predicted amoun
Page 61 and 62: absorbitivity and concentration eff
Page 63 and 64: Compound λ * (nm) Salicylic acid 2
Page 65 and 66: Table 12. Actual and predicted amou
Page 67 and 68: Dividing by C t, where C t is the t
Page 69 and 70: Table 13. Actual and predicted amou
Page 71 and 72: 4.5. Principal component regression
Page 73 and 74: Table 16. Predicted concentrations
Page 75: Component analyzed Pure benzoic aci
Page 79 and 80: 6. REFERENCES 1. Fifield, F.W. and
Page 81 and 82: 26. Danzer, K., Otto, M. and Currie
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CHEMOMETRICS ASSISTED UV-SPECTROPHOTOMETRIC ...

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