CHEMOMETRICS ASSISTED UV-SPECTROPHOTOMETRIC ...

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CHEMOMETRICS ASSISTED UV- SPECTROPHOTOMETRIC DETERMINATION OF TOPICAL BINARY MIXTURES CONTAINING BENZOICACID, SALICYLIC ACID OR RESORCINOL BY Mulualem Kassa Under the supervision of Prof.Dr.Abdel-Maaboud I Mohamed Department of Pharmaceutical Chemistry, School of Pharmacy, AAU A thesis Submitted to the School of Graduate Studies of Addis Ababa University in partial fulfilment of the requirement for the Degree of Master of Science in Pharmaceutical Analysis and Quality Assurance February, 2008
ADDIS ABABA UNIVERSITY SCHOOL OF GRADUATE STUDIES CHEMOMETRICS ASSISTED UV- SPECTROPHOTOMETRIC DETERMINATION OF TOPICAL BINARY MIXTURES CONTAINING BENZOICACID, SALICYLIC ACID OR RESORCINOL By Mulualem Kassa Department of Pharmaceutical Chemistry, School of Pharmacy, AAU Approved by the Examining Board Name Signature Date ___________ ____________ ___________ __________ ____________ ___________ (Examiner) _________ ____________ ___________ (Chairperson)
Page 1: ADDIS ABABA UNIVERSITY SCHOOL OF GR
Page 5 and 6: ACKNOWLEDGEMENTS Above all, my pric
Page 7 and 8: 3.4.2. Preparation of samples......
Page 9 and 10: LIST OF TABLES Table 1. Spectral an
Page 11 and 12: LIST OF FIGURES Fig.1. How chemomet
Page 13 and 14: ABSTRACT Chemometrics-assisted spec
Page 15 and 16: Chemometric is the chemical discipl
Page 17 and 18: Y = a+bx.................. [2] wher
Page 19 and 20: from large sets of data. Using mult
Page 21 and 22: Solving the equations for the K mat
Page 23 and 24: • Calibrations are generally more
Page 25 and 26: The advent of rapid, in expensive c
Page 27 and 28: The derivative spectra are always m
Page 29 and 30: The method is based on the use of t
Page 31 and 32: 2. OBJECTIVES 2.1. General objectiv
Page 33 and 34: 3.4.2. Preparation of samples A. Wh
Page 35 and 36: drug (see the discussion section).
Page 37 and 38: 3 2.5 2 1.5 1 0.5 0 200 215 230 245
Page 39 and 40: Concentration (µg/ml) Fig.15. The
Page 41 and 42: Fig.20. Box plot for pure resorcino
Page 43 and 44: It is obvious from the figures that
Page 45 and 46: From the calculated degree of overl
Page 47 and 48: Compound λ* (nm) Table 1. Spectral
Page 49 and 50: Table 3. Actual and predicted amoun
Page 51 and 52: Compound λ * (nm) Salicylic acid R
Page 53 and 54:
Table 6. Actual and predicted amoun
Page 55 and 56:
The ratio spectra thus obtained are
Page 57 and 58:
0.1 0.0 0.0 0.0 -0.0 -0.0 -0.1 -0.1
Page 59 and 60:
Table.8. Actual and predicted amoun
Page 61 and 62:
absorbitivity and concentration eff
Page 63 and 64:
Compound λ * (nm) Salicylic acid 2
Page 65 and 66:
Table 12. Actual and predicted amou
Page 67 and 68:
Dividing by C t, where C t is the t
Page 69 and 70:
Table 13. Actual and predicted amou
Page 71 and 72:
4.5. Principal component regression
Page 73 and 74:
Table 16. Predicted concentrations
Page 75 and 76:
Component analyzed Pure benzoic aci
Page 77 and 78:
Com pone nt anal yzed SP * Table 20
Page 79 and 80:
6. REFERENCES 1. Fifield, F.W. and
Page 81 and 82:
26. Danzer, K., Otto, M. and Currie
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