Reversible Cerebral Vasoconstriction Syndromes (RCVS)
Reversible Cerebral Vasoconstriction Syndromes (RCVS)
Reversible Cerebral Vasoconstriction Syndromes (RCVS)
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<strong>RCVS</strong> versus PACNS<br />
• 1950s: Primary angiitis of the CNS (PACNS)<br />
uniformly poor outcome; requires prompt<br />
immunosuppressive therapy<br />
• Until late 2000s: <strong>RCVS</strong> under-recognized<br />
(variable nomenclature - Call’s, BACNS, PPA,<br />
vasospasm in eclampsia, TCH, migraine, drugs)<br />
• 1950s-2000s: patients with <strong>RCVS</strong> misinterpreted<br />
as having PACNS due to overlapping features<br />
such as headache, cerebral angiographic<br />
abnormalities, and ischemic stroke<br />
patients with <strong>RCVS</strong> exposed to the risks of brain<br />
biopsy, chronic immunosuppressive therapy
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