Reversible Cerebral Vasoconstriction Syndromes (RCVS)
Reversible Cerebral Vasoconstriction Syndromes (RCVS)
Reversible Cerebral Vasoconstriction Syndromes (RCVS)
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Serotonin – central role in <strong>RCVS</strong>?<br />
Sumatriptan: 5-HT 1B,D receptors<br />
Cocaine, amphetamines: sympathomimetic + serotonergic actions<br />
Diet pills: stroke, “carcinoid” heart & lung lesions (NEJM 1997)<br />
Subarachnoid hemorrhage: ? neuronal serotonin uptake/release<br />
Migraine related stroke: ?serotonergic mechanisms<br />
Head injury: ? release of serotonin from brain, platelets<br />
Porphyria: liver tryptophan pyrrolase is haem-dependant; haem<br />
deficiency in porphyria elevates 5-HT levels (Nature 1983)<br />
Serotonin Syndrome: assoc. with migrainous stroke (Headache 1997)