Reversible Cerebral Vasoconstriction Syndromes (RCVS)
Reversible Cerebral Vasoconstriction Syndromes (RCVS)
Reversible Cerebral Vasoconstriction Syndromes (RCVS)
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Endothelium<br />
• Modulates vascular caliber by producing and<br />
releasing EDRFs such as NO, PGI2, EDHF<br />
• Cerebrovascular endothelial dysfunction might<br />
be related to vasoconstriction in <strong>RCVS</strong>-PRES?<br />
• Increased plasma levels of soluble antiangiogenic<br />
factors (sFlt1, endoglin) documented<br />
in pre-eclampsia and may underlie the<br />
endothelium dysfunction.<br />
(Levin et al. NEJM 2004, 2006; Singhal et al, NEJM 2009)
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