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Reversible Cerebral Vasoconstriction Syndromes (RCVS)

Reversible Cerebral Vasoconstriction Syndromes (RCVS)

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Perivascular Nerves<br />

• Perivascular nerves release various<br />

neurotransmitters and peptides, including 5-HT (Reinhard<br />

et al., Science, 1979, 206: 85)<br />

• Perivascular nerves contain catecholamines, but<br />

vasoconstriction from norepinephrine is poor across<br />

species, including humans (Bevan et al., Stroke, 1998, 29: 212.)<br />

• Interestingly, perivascular sympathetic nerves take<br />

up serotonin both in vitro and during the early phase<br />

of subarachnoid hemorrhage (Szabo et al., Stroke, 1992, 23: 54.)

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