Reversible Cerebral Vasoconstriction Syndromes (RCVS)

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<strong>Cerebral</strong> Arteriopathies • Cause stroke and vascular headache • Overall, the most common cause of stroke – 20% to 50% in older adults (LAA and SVD) – 30% to 40% in young adults – > 50% in children [1] Baltimore-Washington Cooperative Young Stroke Study. [2] Helsinki Young Stroke Registry. [3] International Pediatric Stroke Study. [4] Wong LK. Global burden of intracranial atherosclerosis. Int J Stroke. 2006
Patients (mostly women): rTCH ± stroke/seizure A D B C E ? PACNS CSF, vasculitis labs, brain biopsy negative Some treated with empiric steroids / cyclophosphamide F
Page 1: Reversible Cerebral Vasoconstrictio
Page 5 and 6: Key Elements for Diagnosis 1. Sever
Page 7 and 8: Characteristic Clinical Features CC
Page 9: Laboratory and Imaging Features Cha
Page 12 and 13: Characteristic Follow-up Imaging CC
Page 14 and 15: RCVS: Brain Imaging
Page 16 and 17: Brain Hemorrhage in RCVS Hemorrhage
Page 18 and 19: • Migraine Differential Diagnosis
Page 20 and 21: Diagnostic Approach 1. Clinical Rec
Page 22 and 23: Characteristic Treatment and Outcom
Page 24 and 25: CTA before IA treatment (PPD 20) Si
Page 26 and 27: Final MRI 6 Days After Admission Si
Page 28 and 29: RCVS • Group of conditions charac
Page 31 and 32: Stroke attributed to ‘vasospasm
Page 36 and 37: Hemorrhages in 1 st week, Infarcts
Page 38 and 39: Pathophysiology
Page 40 and 41: A B C (A) Headframe used for bedsid
Page 42 and 43: Perivascular nerves smooth muscle c
Page 44 and 45: Endothelium • Modulates vascular
Page 46 and 47: Spectrum - disorders of cerebrovasc
Page 48 and 49: RCVS and Drugs/Meds Ergot derivativ
Page 50 and 51: Serotonin - central role in RCVS? S
Page 52 and 53:
Serotonergic meds common…but RCVS
Page 54 and 55:
RCVS and Migraine Is RCVS simply a
Page 56 and 57:
Neurology 2006: 67:2164 • Prospec
Page 58 and 59:
RCVS-SAH (n=35) vs. aSAH (n=515)
Page 60 and 61:
RCVS vs. PACNS
Page 63 and 64:
Angio positive in 70 cases; biopsy
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RCVS vs PACNS: MGH cases, 1993-2009
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RCVS vs PACNS: MGH cases, 1993-2009
Page 69 and 70:
Brain lesion topography in RCVS 3.
Page 71 and 72:
Lesion patterns in PACNS 2. Diffuse
Page 73 and 74:
Distinguishing RCVS from PACNS Clin
Page 75 and 76:
Advanced MRI for Cerebral Arteriopa
Page 77 and 78:
To study the phenomena of disease w
Page 79 and 80:
Illustrative Case 46 year male: acu
Page 81 and 82:
Illustrative Case MR angio - severe
Page 84 and 85:
PACNS - Typical Angiographic featur
Page 86:
Treatment vs Poor Outcome All Patie
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Reversible Cerebral Vasoconstriction Syndromes (RCVS)

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