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A quick reference guide to haemofiltration and renal failure March ...

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DIFFUSION<br />

Diffusion is defined as the movement of solutes from an area of<br />

high solute concentration <strong>to</strong> an area of low solute concentration<br />

across a semipermeable membrane. Ultimately, concentration of<br />

the solute will be equal on both sides of the membrane. Diffusion<br />

is directly proportional <strong>to</strong> the concentration gradient,<br />

temperature <strong>and</strong> surface area. Diffusion is inversely proportional<br />

<strong>to</strong> the thickness of the membrane. (Bellomo, Ronco <strong>and</strong> Mehta, 1996:S6)<br />

Low concentration<br />

high concentration equal<br />

concentration<br />

The concentration gradient is maintained in filtration because we<br />

are continually adding fresh dialysate fluid <strong>to</strong> the dialysate side.<br />

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