Notice of Hearing on the Application to Use Sodium Fluoroacetate ...

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1 L9
co~c2ntra:i~ns <strong>of</strong> ff;e;.sc;'trat? ;n zrinkci:~ :~atzr as :cw as six
??n f3r SZVZZ jay5 S ~ C W O 73r3~:9;c~i~2:
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izrzse x 13s ~ 2, s TI; j 5
ait2r 21 days. Rats given sub-lethal dos2s <strong>of</strong> fluorocirrac? in
dr-inking water )lave been shown to srow normally for seven months
and then to survix on an intraperitoneai dose <strong>of</strong> LO rng/kg wnich dcuid
normal iy have been fatal (Peterr, 1971 ) . Thi s i ndi cac3s tha~ a
c2rtsin tolersncs for fluor~ci traze mzy be deveiopea. S~uai 2s ii
by Atzert also shcw that regeated s1~b-121ha; dss2s <strong>of</strong> ~on<strong>of</strong>luoro-
ac2tat2 have increased che talerance <strong>of</strong> scme sgecies, l.g., 9old,. 1 Aaq eagles, rats, mica and possibly rbesus nonkeys. Repea tzd sub-iethal
dosss <strong>of</strong> ~on<strong>of</strong>?uoroacetate in dogs, guinea pigs, rabbi^; ana ~ alard l
ducks, hcwever, accumulatod to lethal levels. 3r. 3ogusky ?oinc?d
out ~hae the reason more data ~wasn' t avai lab1 3 on rlhether fl~oroacs~~:~
accumula~es was because i; ,das so tox'c 2nd chat animals in :he ,di:d
would not normally rzcsive xpeated jub-lethal doses.
Issue 6
139. Sodi urn rnon<strong>of</strong>l uoroacetate i s a xhi t2 , ordor? ess , powdery, f 1 uoro-
organic salt similar in apgearanc? to flour, pcwderad sugar 3r
baking powder. It is essentially tasteless, having only a mild
salty, sour or vinegar taste to individuals. It is highly soluaole
in water, but relatively insoluable in organic solvents such as
kerosene, alcohol, acetone, or in animal and vegetable fats and oi 1 s.
Sodium fluoroacetate is absorbed through the gastrointestinal tract,
through open wounds and the pulminary epithelium, the lining covering