Notice of Hearing on the Application to Use Sodium Fluoroacetate ...

tsxic ;all ar. 2rr. 3ogbsk;i i~juned :ha: :;2 :gfiverzion 2:
fluoroacetece i nto fl uorcci i rat rioul d be on a one-:o-one >;sj i .
He defended this conclusion as reasonable asserting That x e amount
<strong>of</strong> fluoroacatate not converted notild be trivial even tiloti~n he had no
specific data to support that concl usion. Dr. Zimmerman ( findi ng
196) iestified thai dl 1 fluorcacrtaze uoul d nct be ccnverted r3
iluaroci trate and tnat the quantity canverted :vou;d >12ry .vi~h ;he
tissue and the specizs. Dr. Savzrie icated tnat based dccn
nerahol i sii~ studies a small percentage oi fl uoroacetata doul d be
converred to fl uoroci trate. Dr. 3ogusky cansi dered thai dama~e to
kidneys demonstrz~ed by his experiments iould be the same if
i? uoroci trate ar fl uoroacstai? uere xken cral iy . He acknowl edged
that he had not perzomed those experjments and thdi other 5odiiy
functi ons coul d impact i ngesisd F1 uorcci tr3te beiore i I reached
the kidney. He also acknowledged that the cancen~rations sf fluoro-
citrate us2d in his exper'ments on kidneys 3s single organs .~ou'id
hzve been lethal to rats. Alrhotigh Dr. ao~usky is clearly an
experr on kidneys and their functions, he is not an expert on
Compound 1080 or the amount <strong>of</strong> fluoroacetate converted to fluoracitrate
when ingested.
198. Dr. Zirmerman cited a study (Cater, et a1 ., 1961) with rati treated
with f 1 uoroci :rate, whi ch demonstrated marked kidney damage. He
referred ta another test (Sull ivan, 1979) where rats intraduced to