Notice of Hearing on the Application to Use Sodium Fluoroacetate ...

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Senior IOX~ cciog- ST =1)r 722 '4ichl;gsn Szazz : ;::ic S~;cs:ancz Czn-,rc
Csmi s;ion and ?I vj cnfsi for 12ei?ncers, cickncv4j ea;za, ::?z: 5 i 23~7:
07 the aacz zob2 <strong>of</strong> action by whicn Cor~cuna 7380 zx2rrad j; ~ 2 x 1 ~
2ffects were noL knohn. k!e assert2d, how~ver, chat its ,~ecfjanj jn
was generally accsp~ed in the scim~ific csrrnuni ty 2nd I',ha"L i", );as
known that 1080 could. le~hnl ly disrupt basic chemical metabol ism in
a1 1 animal s i ncl u0-i ng man.
137. Dr. Eagusky (f:nding 195) surgiia! 1y removed kidneys frcm ~arrnal TZTi
and perfuszd then [wich an oxygenatsd buff2r solution conu.inin5
serum albumin in an incgbator control led for t2.'i;per?cur~,, ?h and
oxygen. Under thesil candi ti ons , kidneys l~ere i ~ e l to inai n tai n noma i
functions for ac hasi one hour. He added fluoroci trax -,a che
!~r<strong>of</strong>using ~ediurn up to 3 final concenfratj5n <strong>of</strong> 0.1 mM. SurZng che
n
course <strong>of</strong> che experiment kidneys \,vere i nszantly frozen afkr LO
ninut2s <strong>of</strong> perfusion prior co adding fluoroci~rate and at zirned
intervals therzaf~er. Frozen kidneys were axtr2cted and anal yzd
for tissue metabolitzs. He concluded that fluor3cizracs caused a
significant fa1 1 in kidney cissue adenosine tripnosphate (AT?), a
major sourc? <strong>of</strong> energy, to 43 percent <strong>of</strong> normal, that kidney function
was reduced to 7/10 <strong>of</strong> normal and that serious kidney damage had
occurred. The purpose <strong>of</strong> his experiment was to determine how kidneys
produce arranonia rather than to test the 5ffects <strong>of</strong> fluorocitrate on
kidneys. Although Or. Bogusky considered that the concentration <strong>of</strong>
fluarocitrate used was low, it was approximately seven times the one
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