Notice of Hearing on the Application to Use Sodium Fluoroacetate ...

died aftsr T~edjng on kangarso razz po?son?d by 1G80 r~szd as a
rodenticide in Califzrnia and chat c~~yotzs died aft2r fseding zn
ground squirrels poisoned by oats creacsd with 1080 in Montana.
196. The citric acid or Krebs cycle is the final riechanism for converticg
fodd into onergy in plants and animals. Sodium fIuoroac?tate, kvheq -
ingested, is rne-canal i zed i nto fl uoroci t rax, ,rni ch i nnibi ts acti vi :I/
-,
<strong>of</strong> me 2nz;/ne aconi tase and depr'ves cei 1s <strong>of</strong> enerzy. 1 nis znzyne
inhibition results in the blocking <strong>of</strong> the l(r?bs cycle, ;uhich secanbariiy
blocks glucose inetabolisin, a 1,esser energy producing process. 3lockage
<strong>of</strong> cnese orocesszs caus2s che energy supply to be r:ducxi co the ?oint
where cs1lu;ar pemeabiiity barriers are destroyed, resulting in loss
<strong>of</strong> function and iinaiiy c~llular deach. 3ecaus2 <strong>of</strong> chis cell destroyin?
-,
capabii izy, fluorcacet,at2 is ref5rred to as a czl lular poi son. I ne
breakdown in intrac~llular proczssss ?ventually results in the
appearance <strong>of</strong> gross organ or organ systzm disorders. Death may result
from gradual cardi EC fai lure or ventricular fi bri 1 lati on, or progr~ssive
depression <strong>of</strong> the central nervous system wich eizher card'ac or
r~spiratory failure as the terminal event or respiratory arrest
following severe convulsions. Death in carnivorous species is thought
to be the result <strong>of</strong> central nervous system disorders. Dr. Savarie
(finding 192) cautioned that these were assumed modes <strong>of</strong> action based
on tests with rats and had not been proved as to most species. He
asserted that there could be other unidentified metabolites which
contributed to the toxicity <strong>of</strong> rnon<strong>of</strong>luoroacetate. Dr. hlorman Zirmerman ,