Use of nasal and buccal cells in human biomonitoring ... - Formacare
Use of nasal and buccal cells in human biomonitoring ... - Formacare
Use of nasal and buccal cells in human biomonitoring ... - Formacare
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siegfried.knasmueller@meduniwien.ac.at<br />
Overall conclusions<br />
The methods for MN studies with exfoliated <strong>cells</strong> have been<br />
substantially improved <strong>in</strong> the last years by the jo<strong>in</strong>t efforts <strong>of</strong> the<br />
HUMN XL consortium. It was shown that the MN frequencies <strong>of</strong><br />
exfoliated <strong>cells</strong> <strong>of</strong> the oral cavity correlate with <strong>human</strong> cancer<br />
risks <strong>and</strong> are therefore valuable biomarkers for the detection <strong>of</strong><br />
exposure to genotoxic carc<strong>in</strong>ogens. Nasal <strong>cells</strong> have been less<br />
frequently used as oral <strong>cells</strong> but the morphological<br />
characteristics <strong>of</strong> their nuclear anomalies are similar as those<br />
seen <strong>in</strong> <strong>buccal</strong> <strong>cells</strong>. Results obta<strong>in</strong>ed so far with FA exposed<br />
<strong>in</strong>dividuals yielded controversial results; three studies <strong>in</strong> which<br />
positive results were obta<strong>in</strong>ed are <strong>in</strong>adequate due to<br />
methodological shortcom<strong>in</strong>gs.<br />
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