Use of nasal and buccal cells in human biomonitoring ... - Formacare

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Why experiments with exfoliated cells? (comparison of advantages and disadvantages in relation of experiment with lymphocytes) Lymphocytes Buccal/Nasal cells Large database (ca 2100 studies) only around 300 studies Automated evaluation available automated evaluation in preparation sampling invasive sampling not invasive long turnover time of lymphocytes short turnover time (2-3-weeks) Efficient DNA repair low repair capacity of the cells (higher sensitivity) Indirect relation to cancer ≥90% of cancers are of epithelial origin siegfried.knasmueller@meduniwien.ac.at 30
FA studies with exfoliated cells • Since 2006 four further studies were published siegfried.knasmueller@meduniwien.ac.at 31
Page 1 and 2: Use of nasal and buccal cells in hu
Page 3 and 4: siegfried.knasmueller@meduniwien.ac
Page 5 and 6: Not all endpoints are related to ca
Page 9 and 10: Different types of nucelar aberrati
Page 11 and 12: Nat Protoc. 2009;4(6):825-37. 2009
Page 13 and 14: • Staining siegfried.knasmueller@
Page 17 and 18: Number of participants requested si
Page 19 and 20: Methodological aspects: experiments
Page 27 and 28: Chicken manure B: ─ / N ─ Studi
Page 29: Which cell types are more sensitive
Page 33 and 34: Micronucleus frequencies in exfolia

Use of nasal and buccal cells in human biomonitoring ... - Formacare

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