Use of nasal and buccal cells in human biomonitoring ... - Formacare
Use of nasal and buccal cells in human biomonitoring ... - Formacare
Use of nasal and buccal cells in human biomonitoring ... - Formacare
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siegfried.knasmueller@meduniwien.ac.at<br />
Sta<strong>in</strong><strong>in</strong>g<br />
a b<br />
c<br />
Figures a <strong>and</strong> c depict May-Grünwald-Giemsa sta<strong>in</strong>ed <strong>cells</strong>.<br />
Figures b <strong>and</strong> d show the same <strong>cells</strong> after sta<strong>in</strong><strong>in</strong>g with Feulgen <strong>and</strong><br />
DAPI.<br />
d<br />
A large number <strong>of</strong><br />
earlier studies used<br />
DNA unspecific sta<strong>in</strong>s<br />
(e.g. Giemsa) which<br />
lead to false positive<br />
results (as they sta<strong>in</strong><br />
kerat<strong>in</strong> bodies that are<br />
formed <strong>in</strong> epithelial<br />
<strong>cells</strong> as a consequence<br />
<strong>of</strong> cytotoxicity.<br />
Nersesyan et al. Cancer Epidemiol Biomarkers Prev<br />
2006;15(10). October 2006<br />
14
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