IVRI 2318.pdf
IVRI 2318.pdf
IVRI 2318.pdf
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INTRAPERICARDIAL MEDICATION AND MASSAGE 39<br />
Experiment 4, Figure 3. This experiment was made to determine<br />
whether adrenine acts on the heart when introduced iuto<br />
the pericardial sac.<br />
The heart-rate before injection was 39 per ten seconds. Pilocarpine<br />
nitrate (0.4 cc. of a one per cent solution) was injected<br />
intravenously (fig. 3 a). In half a minute this had reduced the<br />
heart-rate to 15 per ten seconds, and adrenine (1 cc. of a 1 in<br />
2000 solution) was injected into the pericardial sac (b). In<br />
thirty seconds the heart-rat'e had increased to 22 (0), and in two<br />
minutes to 37, Cd), per ten seconds.<br />
Adrenine here produced a definite acceleration of the heart<br />
when applied to its external surface. The fact that the bloodpressure<br />
rose to above the normal suggests that some adrenine<br />
may have been absorbed into the general circulation, though it<br />
may on the other hand have been due to an augmentor action<br />
on the heart itself.<br />
Experiment 5, Figure 4. This experiment was performed on<br />
a cat, the conditions of experiment being the same as in previous<br />
experiments. In the more slowly beating heart of the cat, it is<br />
easy to show the accelerating action of adrenine without previous<br />
use of pilocarpine.<br />
For five minutes before injection the heart-rate had remained<br />
regularly 23 or 24 per ten seconds. Adrenine (1 cc. of a 1 in<br />
10,000 solution) was injected into the pericardial sac. In thirty<br />
seconds this increased the heart-rate to 32 per ten seconds (fig.<br />
4). The effect of adrenine in this experiment is clearly due to<br />
a local action on the heart, the acceleration being very considerable<br />
but the rise of blood-pressure only very slight.<br />
These and other experiments have furnished sufficient grounds<br />
for believing that at all events atropine, pilocarpine and adrenine<br />
can exert their actions on the heart when introduced into<br />
the pericardial sac. In regard to the present inquiry adrenine<br />
was the most interesting; one of us has in recent years conducted<br />
a series of experiments to determine which is the most powerful<br />
cardiac stimulant from the point of view of its value in starting<br />
an arrested heart; and, of those drugs which have been ttied,<br />
adrenine has proved unquestionably the best. Thus it has been