Genomics – A New Era for Cattle Breeding. Session - ICBF

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Moving IHFA to SNP’s for males. • Of the 5.5k pedigree males born/annum, 10% are genotyped, 56% sires are genotyped & 97% sires have a genotype or micro-satellite. • IHFA already undertaking parentage verification on 100% males. – No “long-term” impact on male registrations. – Part of overall registration fee. • Opportunity for “seamless” move to SNP’s. More benefits for members. – Suggested sires with SNP’s, MGS validation. • Other dairy breeds – follow beef model. 128
Quantifying the Benefits. A quick summary. • Parentage verification on all breeding males. • Major genes & recessives. – Screening out & new genes. – Genomic mating’s. • Genomic indexes (in time). – Selecting the best. • Further quantification of benefits, including examples in part II. 129
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Genomics - A New Era for Cattle Bre
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Session 1. Genomics & parentage ide
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Introduction to Animal Breeding & G
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Traditional Animal Breeding • Cal
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Using technology of today • At bi
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How do we use this DNA information?
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What is a SNP? • 99.9% of human D
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SNP effect on performance SNP Var M
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Indentifying Mendelian sampling ter
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Cost of sequencing has decreased Bu
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Sire …..TCACCGCTGAG….. …..CAG
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Parentage Sire 1 Sire 2 Sire 3 Sire
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Recessive genetic disorders AB AB A
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To Conclude • Differences seen be
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Genomic Advances in Parentage Verif
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U.S. Department of Agriculture, Agr
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Blood Typing >1990’s Used to dete
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Used to detect bi-allelic polymorph
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Technology Transfer via Imputation
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Impute ISAG cattle MS alleles from
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SNP haplotype to MS allele BM1824 I
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Validate Cattle with SNP and MS on
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Validate Phase, impute, check 316 S
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Validate Phase, impute, check 316 S
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Validation with DAIRY table Order:
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Microsatellite Imputation 2 nd Stud
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Initial Results 642 456 312 233 220
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Acknowledgements • BFGL (USDA-ARS
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Parentage verification Genomic sele
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LD+ content (V1-19K) • Genomic se
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Proportion allele concordance 1.00
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• CVM • BLAD Lethal Recessives
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Major genes • 14 major genes incl
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From just 1 hair sample! Calf ID CV
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Conclusions • Custom chip - value
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Implementation of Genomic Services
Page 77 and 78: What is Genotyping? • Identifying
Page 79 and 80: Typical example of processing a Bov
Page 81 and 82: ICBF & Teagasc Genomics Conference
Page 93 and 94: Work Flow Summary • Sample assign
Page 95 and 96: IRISH CATTLE BREEDING FEDERATION Ge
Page 97 and 98: © Irish Cattle Breeding Federation
Page 99 and 100: User friendly, fully integrated, tr
Page 101 and 102: AI Company/Breed Society Order Scre
Page 103 and 104: HerdPlus® User genotype request sc
Page 111 and 112: VIEW YOUR RESULTS Genomic Evaluatio
Page 115 and 116: Chip Type Number of animals genotyp
Page 117 and 118: LIST OF BEEF BULLS WANTED Contact I
Page 121 and 122: Genomics & Breeding Programs • Ge
Page 123 and 124: Pedigree dairy registrations (2011)
Page 125 and 126: Moving Beef to SNP’s for parentag
Page 127: Moving beef industry to SNP’s for
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Genomics – A New Era for Cattle Breeding. Session - ICBF

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