Genomics – A New Era for Cattle Breeding. Session - ICBF

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Moving industry to SNP’s (process). 1. Pedigree registration through Animal Events. 2. Database generates DNA kit to farmer. 3. Farmer returns DNA kit to HB/ICBF, with payment. 4. HB/ICBF forward hair samples to Weatherby’s. 5. Weatherby’s extract DNA. Generate genotype. Parentage verification off ICBF database. Database confirms parentage, suggests alternative or generates error. HB/ICBF communicate with farmer. 6. Valid registration, load to ICBF database & generate genomic index. Invalid registration, follow up by HB/ICBF. 7. HB generates pedigree cert & completes charge for service. 8. ICBF & HB generate genomic report. Posted on websites 126
Moving beef industry to SNP’s for males (costs) • Proposition to move all pedigree beef males to “new” genomic service. • 15k pedigree males in 2013. • “Full cost” of service = €40/animal (chip, extraction, post, pack, administration, gen EBI & initial 20% errors) = €600k. • Beef farmers currently paying €120k (for MS based services). How do we “close the gap”? • Establish a 5 year plan, including relevant funding models. 127
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Genomics - A New Era for Cattle Bre
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Session 1. Genomics & parentage ide
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Introduction to Animal Breeding & G
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Traditional Animal Breeding • Cal
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Using technology of today • At bi
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How do we use this DNA information?
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What is a SNP? • 99.9% of human D
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SNP effect on performance SNP Var M
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Indentifying Mendelian sampling ter
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Cost of sequencing has decreased Bu
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Sire …..TCACCGCTGAG….. …..CAG
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Parentage Sire 1 Sire 2 Sire 3 Sire
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Recessive genetic disorders AB AB A
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To Conclude • Differences seen be
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Genomic Advances in Parentage Verif
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U.S. Department of Agriculture, Agr
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Blood Typing >1990’s Used to dete
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Used to detect bi-allelic polymorph
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Technology Transfer via Imputation
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Impute ISAG cattle MS alleles from
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SNP haplotype to MS allele BM1824 I
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Validate Cattle with SNP and MS on
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Validate Phase, impute, check 316 S
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Validate Phase, impute, check 316 S
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Validation with DAIRY table Order:
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Microsatellite Imputation 2 nd Stud
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Initial Results 642 456 312 233 220
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Acknowledgements • BFGL (USDA-ARS
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Parentage verification Genomic sele
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LD+ content (V1-19K) • Genomic se
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Proportion allele concordance 1.00
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• CVM • BLAD Lethal Recessives
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Major genes • 14 major genes incl
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From just 1 hair sample! Calf ID CV
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Conclusions • Custom chip - value
Page 75 and 76: Implementation of Genomic Services
Page 77 and 78: What is Genotyping? • Identifying
Page 79 and 80: Typical example of processing a Bov
Page 81 and 82: ICBF & Teagasc Genomics Conference
Page 93 and 94: Work Flow Summary • Sample assign
Page 95 and 96: IRISH CATTLE BREEDING FEDERATION Ge
Page 97 and 98: © Irish Cattle Breeding Federation
Page 99 and 100: User friendly, fully integrated, tr
Page 101 and 102: AI Company/Breed Society Order Scre
Page 103 and 104: HerdPlus® User genotype request sc
Page 111 and 112: VIEW YOUR RESULTS Genomic Evaluatio
Page 115 and 116: Chip Type Number of animals genotyp
Page 117 and 118: LIST OF BEEF BULLS WANTED Contact I
Page 121 and 122: Genomics & Breeding Programs • Ge
Page 123 and 124: Pedigree dairy registrations (2011)
Page 125: Moving Beef to SNP’s for parentag
Page 129 and 130: Quantifying the Benefits. A quick s
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Genomics – A New Era for Cattle Breeding. Session - ICBF

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