Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Beyond IUI, IVF and ICSI - New developments in - eshre 2013
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VI. HA <strong>and</strong> <strong>IVF</strong> outcome: retrospective study<br />
(20 samples, Time1= raw sample, T2= the time of <strong>in</strong>sem<strong>in</strong>ation).<br />
No correlation for %HA-b<strong>in</strong>d<strong>in</strong>g <strong>in</strong><br />
the raw sample or after gradient<br />
centrifugation (at the time of<br />
<strong>in</strong>sem<strong>in</strong>ation)<br />
No correlation for fertilization rates<br />
VII. HA <strong>and</strong> <strong>IVF</strong> outcome (under Italian law)<br />
Tarozzi et al. Reprod Biomed Onl<strong>in</strong>e 2009 (19) suppl 3:35-43<br />
60 <strong>IVF</strong> patients<br />
HA-b<strong>in</strong>d<strong>in</strong>g test <strong>in</strong> an aliquot semen, TUNEL<br />
No relationship between HA-b<strong>in</strong>d<strong>in</strong>g with fertilization,<br />
cleavage, embryo quality, cl<strong>in</strong>ical pregnancy,<br />
miscarriages.<br />
Limited predictive value/ limited cl<strong>in</strong>ical use<br />
VIII. HA <strong>and</strong> <strong>ICSI</strong> outcome (under Italian law)<br />
1) Tarozzi et al. Reprod Biomed Onl<strong>in</strong>e 2009 (19) suppl 3:35-43<br />
2) Parmegiani et al. Fertil Steril 2010 93(2):598-604<br />
1) 293 <strong>ICSI</strong> couples HA-selected vs 86 st<strong>and</strong>ard <strong>ICSI</strong><br />
HA-b<strong>in</strong>d<strong>in</strong>g test <strong>in</strong> an aliquot semen, TUNEL<br />
2) 206 <strong>ICSI</strong> couples<br />
Conclusion both studies: HA-bound sperm significantly<br />
improved embryo quality <strong>and</strong> implantation<br />
Predictive cl<strong>in</strong>ical value<br />
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