Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
III. HA <strong>and</strong> <strong>ICSI</strong> outcome: prospective r<strong>and</strong>omized<br />
study<br />
Van den Bergh et al . Reprod. Biomed. Onl<strong>in</strong>e 2009 19(6): 796-801<br />
Nasr-Esfahani et al. J Assit Reprod Genet 2008 25 (5):197-203<br />
44 Patients: <strong>ICSI</strong> with ½ HA-bound sperm (HA+)<br />
½ unbound sperm (HA -)<br />
• % fertilization: HA(+) 75% HA(-) 70%<br />
• Zygote score, embryo quality <strong>and</strong> # 4c- embryos: similar<br />
<strong>in</strong> both groups<br />
HA(+) higher fertilization rate; pregnancy rate not different<br />
Limited predictive value/ limited cl<strong>in</strong>ical use<br />
IV. HA <strong>and</strong> ART outcome: freezability of sperm<br />
Yogev et al. Fertil Steril 2010 93(1): 154-8<br />
Sperm donors (129) : semen analysis <strong>and</strong> % HA-bound<br />
sperm<br />
Predictive value HA-b<strong>in</strong>d<strong>in</strong>g significant, significant but not better than<br />
% motility after 1- to 4 hours<br />
Limited predictive value/ limited cl<strong>in</strong>ical use<br />
Va. HA <strong>and</strong> <strong>IVF</strong> outcome<br />
Ye et al. Hum Reprod. 2006 21(6): 1545-50<br />
175 <strong>IVF</strong> patients: 3 or > oocytes.<br />
HA-b<strong>in</strong>d<strong>in</strong>g test <strong>in</strong> an aliquot semen<br />
HA-b<strong>in</strong>d<strong>in</strong>g correlates with motility <strong>and</strong> morphology<br />
Poor predictive value of HA-b<strong>in</strong>d<strong>in</strong>g for poor fertilization<br />
Limited predictive value/ limited cl<strong>in</strong>ical use<br />
Page 55 of 127
Change language