Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
HA-b<strong>in</strong>d<strong>in</strong>g <strong>and</strong> predictive value for ART:<br />
the “P<strong>ICSI</strong>” dishes<br />
I. HA <strong>and</strong> ART outcome: prospective study<br />
Nijs et al. Andrologia 2010 42(5):29-6<br />
68 patients: ½ <strong>IVF</strong> <strong>and</strong> ½ <strong>ICSI</strong> (evaluation of HA-b<strong>in</strong>d<strong>in</strong>g <strong>in</strong> neat sample)<br />
Semen analysis: HA –b<strong>in</strong>d<strong>in</strong>g not correlated to morphology, concentration or motility<br />
% fertilization: HA b<strong>in</strong>d<strong>in</strong>g not predictable for fertilization failure<br />
Embryo quality: correlation with HA-b<strong>in</strong>d<strong>in</strong>g<br />
Ongo<strong>in</strong>g pregnancy or Cumulative pregnancy rate: no correlation with HA-b<strong>in</strong>d<strong>in</strong>g<br />
Limited predictive value/ limited cl<strong>in</strong>ical use<br />
II. HA <strong>and</strong> ART outcome: prospective, bl<strong>in</strong>ded<br />
controlled trial<br />
Kovacs et al. J. Assist Reprod Genet 2011 28(1): 49-54<br />
Patients with unexpla<strong>in</strong>ed <strong>in</strong>fertility: ½ <strong>IVF</strong> <strong>and</strong> ½ <strong>ICSI</strong><br />
(evaluation of HA-b<strong>in</strong>d<strong>in</strong>g <strong>in</strong> neat sample)<br />
• HA HA-b<strong>in</strong>d<strong>in</strong>g bi di cut-off: t ff < 60%, 60% 60 60-80%, 80% >80% 80%<br />
• % fertilization: HA b<strong>in</strong>d<strong>in</strong>g not predictable for <strong>IVF</strong> fertilization<br />
• Embryo quality: similar <strong>in</strong> all cut-off groups<br />
Limited predictive value/ limited cl<strong>in</strong>ical use<br />
Page 54 of 127