Beyond IUI, IVF and ICSI - New developments in - eshre 2013

HA-binding and predictive value for ART:
the “PICSI” dishes
I. HA and ART outcome: prospective study
Nijs et al. Andrologia 2010 42(5):29-6
68 patients: ½ IVF and ½ ICSI (evaluation of HA-binding in neat sample)
Semen analysis: HA –binding not correlated to morphology, concentration or motility
% fertilization: HA binding not predictable for fertilization failure
Embryo quality: correlation with HA-binding
Ongoing pregnancy or Cumulative pregnancy rate: no correlation with HA-binding
Limited predictive value/ limited clinical use
II. HA and ART outcome: prospective, blinded
controlled trial
Kovacs et al. J. Assist Reprod Genet 2011 28(1): 49-54
Patients with unexplained infertility: ½ IVF and ½ ICSI
(evaluation of HA-binding in neat sample)
• HA HA-binding bi di cut-off: t ff < 60%, 60% 60 60-80%, 80% >80% 80%
• % fertilization: HA binding not predictable for IVF fertilization
• Embryo quality: similar in all cut-off groups
Limited predictive value/ limited clinical use
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