Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Beyond IUI, IVF and ICSI - New developments in - eshre 2013
Beyond IUI, IVF and ICSI - New developments in - eshre 2013
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HA-bound sperm <strong>and</strong> morphology with MSOME evaluation<br />
Petersen et al. Reproductive Biology <strong>and</strong> Endocr<strong>in</strong>ology 2010 8:149<br />
16.592 sperm/56 patients<br />
5579 HA-bound sperm<br />
2.7% presented normal<br />
morphology h l<br />
No statistical difference <strong>in</strong><br />
morphology between<br />
bound/not bound sperm<br />
HA-bound sperm <strong>and</strong> aneuploidy<br />
HA-selected spermatozoa reduced 4- to 6 fold the frequency of chromosomal<br />
aneuploidy<br />
Conclusions diagnostic test<br />
Jakab, et al. Fertil Steril 2005<br />
84(6):1665-73<br />
Huszar et al. Reprod Biomed<br />
Onl<strong>in</strong>e 2007 14(5):650-63<br />
The HA-b<strong>in</strong>d<strong>in</strong>g test is a promis<strong>in</strong>g diagnostic<br />
tool <strong>in</strong> assess<strong>in</strong>g fertility potential <strong>in</strong> sperm<br />
samples<br />
Sperm with the capacity to b<strong>in</strong>d to a monolayer<br />
of hyaluronic acid present low percentage of<br />
DNA-damage <strong>and</strong> higher chromat<strong>in</strong><br />
condensation<br />
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