Beyond IUI, IVF and ICSI - New developments in - eshre 2013

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IMSI: Clinical results Some studies have analyzed the impact of IVF‐IMSI procedure on ICSI outcomes in terms of: fertilization rate, embryo development, pregnancy rate, iimplantation l i rate andd abortion b i rate. After 11 years is IMSI application based on clinical evidences? Meta‐analysis Studies included in the meta‐analysis Souza Setti et al., 2010 Page 36 of 127
Conclusions of the meta‐analysis • The current meta‐analysis can conclude that IMSI not only significantly improves the percentage of top‐ quality embryos, implantation and pregnancy rates, but also significantly reduces miscarriage rates as compared with ICSI. • However, a weakness of this meta‐analysis is the variable study’s characteristic. Since the advent of IMSI, only one randomized controlled trial was published. Thus, to perform this meta‐analysis, comparative studies in which IMSI cycles were matched with ICSI cycles also had to be included. 168 Cycles ICSI (87 cycles) IMSI (81 cycles) Characteristics ICSI IMSI Souza Setti et al., 2010 IMSI: Prospective randomized study Female age 28.80±4.08 29.67±4.03 Male age 32.53±4.87 33.97±5.52 Aetiology of infertility Male factor 39(48.1) 38(43.7) Ovulatory 1 (1.2) 2 (2.3) Tubal 10 (12.3) 7 (8.0) Unexplained 24 (29.6) 30 (34.5) Multiple factors 7 (8.6) 10 (11.5) Laboratory and clinical outcome Balaban et al., 2011 Outcome ICSI IMSI P‐value Duration of ICSI procedure (min) 13.55 ± 5.43 20.54 ± 9.43 < 0.001 Fertilization rate (%) 80.97 ± 15.06 81.60 ± 10.65 NS Grade 1 and 2 embryos on transfer day y (%) ( ) 4.84 (63.95) 5.01 (66.44) NS Mean no.of embryos transferred 2.76 ± 0.46 2.72 ±0.48 NS Clinical pregnancy per initiated cycle (%) 36/81 (44.4) 47/87 (54.0) NS Live birth rate per initiated cycle (%) 31/81 (38.3) 38/87 (43.7) NS Implantation rate (%) 42/215 (19.5) 66/228 (28.9) NS Multiple pregnancy rate (%) 6/36 (16.7) 16/47(34.0)
Page 1: 28th Annual Meeting of the European
Page 5 and 6: Contents Course coordinators, cours
Page 7 and 8: Course coordinators Herman Tournaye
Page 9 and 10: Scientific programme Sperm selectio
Page 11 and 12: ESHRE SIG Andrology, Istanbul, Turk
Page 13 and 14: October 2001 - “A Physics Revelat
Page 15 and 16: Polydimethylsiloxan and Sperm Survi
Page 17 and 18: Microfluidic Sperm Isolation Reduce
Page 19 and 20: Micro-insemination Device 1. Remove
Page 21 and 22: Selecting spermatozoa; potential ro
Page 23 and 24: Fertilization Rate (%) 120 100 80 6
Page 25 and 26: Spermsep CS10 System Sperm Cell Sep
Page 27 and 28: TUNEL (%) 14% 90 80 70 60 50 40 30
Page 29 and 30: Cathode (- ve terminal) Anode (+ ve
Page 31 and 32: Hydrogen peroxide mediates DNA dama
Page 33 and 34: ESHRE 2012: Pre‐congress course 2
Page 35 and 36: Sperm morphology and ICSI The estab
Page 37: Motile Sperm Organellar Morphology
Page 41 and 42: Does the presence of sperm nuclear
Page 43 and 44: Basic sperm parameters Sperm DNA fr
Page 45 and 46: No relationship between chromosome
Page 47 and 48: Gynecology: Filippo Ubaldi Elena Ba
Page 49 and 50: Sperm selection: why? There is an i
Page 51 and 52: I- MACS -Annexine V for diagnostic
Page 53 and 54: Evaluation of HA-binding and sperm
Page 55 and 56: HA-bound sperm and morphology with
Page 57 and 58: III. HA and ICSI outcome: prospecti
Page 59 and 60: HA- clinical uses and limitations
Page 61 and 62: May the force be with you Using imm
Page 63 and 64: Sperm ultrastructure Centrosome cha
Page 65 and 66: Diagnostic semen analysis Three ba
Page 67 and 68: Ultrastructural defects Transmissio
Page 69 and 70: Necrozoospermia / low viability rat
Page 71 and 72: 1. Hypo-osmotic swelling test ICSI
Page 73 and 74: 4. Laser-assisted selection (LAISS)
Page 75 and 76: 5. Birefringence-polarisation micro
Page 77 and 78: Conclusions Absolute asthenozoospe
Page 79 and 80: Definition of Azoospermia: Absence
Page 81 and 82: Cases of aspermia Preventive measur
Page 83 and 84: The probability crypto azoospermic
Page 85 and 86: "The beauty and the beast" when the
Page 87 and 88: Fertilization rate after ICSI 1- Oo
Page 89 and 90:
With (ICSI), zona pellucida penetra
Page 91 and 92:
Sibling oocytes from each patient w
Page 93 and 94:
The electron microscopic results in
Page 95 and 96:
Ionophore treatment for oocyte acti
Page 97 and 98:
The oocytes were suspended in 0.3M
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Table 3. Pregnancy rates and outcom
Page 101 and 102:
References • Devroey P, Van Steir
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Longing for a girl: Gender selectio
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1,1 1 0,9 0,8 0,7 0,6 Sex ratio imb
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PhD Thesis Michelle Duc, 1977 Retro
Page 109 and 110:
Reasons for wanting a girl at GC
Page 111 and 112:
Assessment of cervical mucus OOpaqu
Page 113 and 114:
Study design • A reference group
Page 115 and 116:
Partial data Reason n No post‐pre
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Percentage P of girls 70 60 50 40 3
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New aspects of this research • Fi
Page 121 and 122:
Mark your calendar for the upcoming
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NOTES Page 121 of 127
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Beyond IUI, IVF and ICSI - New developments in - eshre 2013

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