Plants with toxic alkaloids - University of Washington

Plants with toxic alkaloids - University of Washington Plants with toxic alkaloids - University of Washington

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1. Hormones Thyroid hormone thyroxin over dosage from animal product will cause symptoms of iodine poisoning Insulin overdosing from animal source will cause deathlike stage of low blood sugar 2. Blood contamination of open wound will often cause hemolysis in humans; eel Anguila or tuna blood Roe of Tetraodon or puffer fish is famous suicide poison in Japan, barbus, pike and other species is often toxic

What makes plants toxic? alkaloids (nicotin) , oxalate crystals (Areacea), proteins (ricin Ricinus, abrin (Abrus rosary pea), polypeptides ( phallotoxin of Amanitas); amines and non-proteinogenic AAs (Fabaecea), resins (oily urushiol form poison ivy), minerals (selenium accumulation in Astralagus), alcohols (cicutoxin in Cicuta water hemlock, tremetol in Eupatorium snakeroots), glycosides What does toxic mean to us? Paracelsus: Acting as a toxin or medicine is matter of dosage! Homeopathy: Hahnemann “like cures like”, diluted poisons have a similar vaccine-like effect comparable to weakened germs Paul Ehrlich 1898 (“magic bullet”) started studies on antitoxic immunity got immunity by feeding abrin & ricin to mice, …serum develops antibodies against protein. plant toxins

What makes plants <strong>toxic</strong>?<br />

<strong>alkaloids</strong> (nicotin) , oxalate crystals (Areacea), proteins (ricin<br />

Ricinus, abrin (Abrus rosary pea), polypeptides ( phallotoxin <strong>of</strong><br />

Amanitas); amines and non-proteinogenic AAs (Fabaecea),<br />

resins (oily urushiol form poison ivy), minerals (selenium<br />

accumulation in Astralagus), alcohols (cicutoxin in Cicuta water<br />

hemlock, tremetol in Eupatorium snakeroots), glycosides<br />

What does <strong>toxic</strong> mean to us?<br />

Paracelsus: Acting as a toxin or medicine is matter <strong>of</strong> dosage!<br />

Homeopathy: Hahnemann “like cures like”, diluted poisons have<br />

a similar vaccine-like effect comparable to weakened germs<br />

Paul Ehrlich 1898 (“magic bullet”) started studies on anti<strong>toxic</strong><br />

immunity got immunity by feeding abrin & ricin to mice,<br />

…serum develops antibodies against protein. plant toxins

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