Health Assessment Document for Diesel Emissions - NSCEP | US ...
Health Assessment Document for Diesel Emissions - NSCEP | US ...
Health Assessment Document for Diesel Emissions - NSCEP | US ...
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Parametera<br />
llo<br />
a<br />
b<br />
llz<br />
qo<br />
ql<br />
Yo<br />
Y1<br />
ex<br />
Nb (given)<br />
Table B-2. Maximum likelihood estimates <strong>for</strong> model parameters<br />
Estimate<br />
1.033E-7<br />
1.103E+4<br />
3.214E+2<br />
7.907E-7<br />
1.035E-1<br />
5.332E-2·<br />
1.662E-2<br />
2.647<br />
5.443E-1<br />
8.80E+7<br />
aBackground parameters llo• q 0 , and Yo are estimated separately from NTP historical control data.<br />
bThe number of target cells N is assumed to be 10-fold of Type II cells in mice, which is given in Kauffman (1974).<br />
It is not essential <strong>for</strong> N to be given accurately because N llo appears as a single term in the model; the estimated llo<br />
will compensate <strong>for</strong> the under- or over-estimation ofN.<br />
Initiation<br />
Proliferation<br />
T a bl e B - 3 . R e I a t. 1ve magm ·t u d e o f" 1m ·ti a t· 10n<br />
11 ' (d,D) ·<br />
llo<br />
an d pro I"fi 1 era ti on .<br />
(r[D]Ir 0 ) potential <strong>for</strong> the exposed versus control groups in Mauderly et al.<br />
(1987) study<br />
Exposed Groups<br />
Time Interval Low Mid High<br />
1 1.048 1.639 2.442<br />
2 1.056 2.168 3.570<br />
3 1.056 2.654 4.556<br />
4 1.056 3.084 5.405<br />
5 1.056 3.419 6.433<br />
1 1.004 1.052 1.137<br />
2 1.006 1.166 1.379<br />
3 1.006 1.270 1.590<br />
4 1.006 1.362 1.770<br />
5 1.006 1.424 1.989<br />
2/1198 B-7 DRAFT --DO NOT CITE OR QUOTE
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