Health Assessment Document for Diesel Emissions - NSCEP | US ...
Health Assessment Document for Diesel Emissions - NSCEP | US ...
Health Assessment Document for Diesel Emissions - NSCEP | US ...
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Table 11-2. Incidence of lung tumors in Fischer 344 rats (males and females<br />
combined) exposed to heavy-duty engine exhaust<br />
Dose metric<br />
Exposure Lung particle<br />
concentration Weekly exposure burden (mglcm2 Lung tumor<br />
(mglm3 ) (mglm3 x ht · lung surfacet incidencec<br />
0 0 0 2/230<br />
0.35 12 6.4 x 10· 5<br />
3.50 122 2.8 X IQ· 3<br />
7.08 248 6.Q X 10" 3<br />
3/223<br />
6/222<br />
18/227<br />
aExposures were 7 hours/day, 5 days/week <strong>for</strong> 30 months. Numbers include those dy.ing or moribund prior<br />
to 30 months.<br />
bCalculated using mathematical models in Appendix C.<br />
cDoes not include squamous cysts.<br />
Source: Mauderly et al., 1987 .<br />
. Table 11-3. Incidence oflung tumors in Fischer 344 rats (males and females<br />
combined) exposed to heavy-duty engine exhaust<br />
Dose metric<br />
Exposure Lung particle<br />
concentration Weekly exposure burden (mglcm 2 Lung tumor<br />
(mg/m 3 ) (mg/m 3 x ht lung surface t incidencec<br />
0 0 0 11123<br />
0.46 44 2.5 X IQ· 4<br />
0.96 92 2.0 x 10· 3<br />
1.84 177 4.2 X IQ· 3<br />
3.72 357 8.8 X 10" 3<br />
1/123<br />
0/125<br />
4/123<br />
8/124<br />
•Exposures were 16 hours/day, 6 days/week <strong>for</strong> 30 months. Numbers include those dying or sacrificed moribund<br />
be<strong>for</strong>e 30 months.<br />
bCalculated using mathematical models in Appendix C.<br />
cAll tumors reported were carcinomas.<br />
Source: Ishinishi et al., 1986.<br />
2/1198 11-13 DRAFT--DO NOT CITE OR QUOTE
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