Health Assessment Document for Diesel Emissions - NSCEP | US ...
Health Assessment Document for Diesel Emissions - NSCEP | US ...
Health Assessment Document for Diesel Emissions - NSCEP | US ...
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1 Caution must be exercised in extrapolating observations made in animal models to<br />
2 . humans when assessing the potential <strong>for</strong> DE-induced pulmonary carcinogenesis. The<br />
3 carcinogenic response and the <strong>for</strong>mation of DNA adducts in rats exposed to diesel exhaust and<br />
4 other particles at high exposure concentrations may be species-specific and not particle-specific.<br />
5 However, DNA adduct data and the possible involvement of reactive oxygen species maybe<br />
6 relevant in long-term occupational exposure of humans to low concentrations.<br />
7<br />
8 1 0.6. REFERENCES<br />
9<br />
1 0 Adamson, IYR; Bowden, DH. ( 1978) Adaptive response of the pulmonary macrophagic system to carbon. II.<br />
11 Morphologic studies. Lab Invest 38:430-438.<br />
12<br />
13 Allen, RC; Loose, LD. (1976) Phagocytic activation of a luminol-dependent chemiluminescence in rabbit alveolar<br />
14 and peritoneal macrophages. Biochem Biophys Commun 69:245-252.<br />
15<br />
16 Ball, LM; King, LC. (1985) Metabolism, mutagenicity, and activation of 1-nitropyrene in vivo and in vitro. Environ<br />
17 Int ll :355-362.<br />
18<br />
19 Beall, GO; Repine, JE; Hoidal, JR; Raps, FL. ( 1977) Chemiluminscence by human alveolar macrophages:<br />
20 stimulation with heat killed bacteria or phorbol myristate acetate. Infect Immunol 17:117-120.<br />
21<br />
22 Bitterman, PB; Aselberg, S; Crystal, RG. (1983) Mechanism of pulmonary fibrosis: spontaneous release of the<br />
23 alveolar macrophage-derived growth factor in interstitial lung disorders. J Clin Invest 72: 1801-1813.<br />
24<br />
25 Bohning, DE; Atkins, HL; Cohn, SH. ( 1982) Long-term particle· clearance in man: normal and impaired. Ann Occup<br />
26 Hyg 26:259-271.<br />
27<br />
28 Boldt,J; Mah, MC; Wang, YC; Smith, BA; Beland, FA; Maher, VM; McCormick, JJ. (1991) Kinds of mutations<br />
29 found when a shuttle vector containing adducts of 1,6-dinitropyrene replicates in human cells. Carcinogenesis<br />
30 12:119-126.<br />
31<br />
32 Bond, JA. (1993) DNA adducts. In: U.S. EPA research needs <strong>for</strong> risk assessment of inhaled particulate matter.<br />
33 Washington, DC: Office of <strong>Health</strong> and Environmental <strong>Assessment</strong>; EPA/600/R-93/104.<br />
34<br />
35 Bond, JA; Mauderly, JL. ( 1984) Metabolism and macromolecular covalent binding of[ 14 C]-l-nitropyrene in isolated<br />
36 . perfused and ventilated rat lungs. Cancer Res 44:3924-3929. ·<br />
37<br />
38 Bond, JA; Mitchell, CE; Li, AP. (1983) Metabolism and macromolecular covalent binding ofbenzo[a]pyrene in<br />
39 cultured Fischer-344 rat lung type II epithelial cells. Biochem Pharmacol32:3771-3776.<br />
40<br />
41 Bond, JA; Butler, MM; Medinsky, MA; Muggenburg, BA; McClellan, RO. (1984) Dog pulmonary macrophage<br />
42 metabolism of free and particle-associated [ 14 C]benzo[a]pyrene. J Toxicol Environ <strong>Health</strong> 14:181-189.<br />
43<br />
44 Bond, JA; Sun, JD; Mitchell, CE; Dutcher, JS; Wolff, RK; McClellan, RO. (1986) Deposition, metabolism and<br />
45 excretion of 14 C-1-nitropyrene coated on diesel particles as influenced by exposure concentration. Toxicol Appl<br />
46 Pharmacol 85: 102-117.<br />
47<br />
48 Bond, JA; Wolff, RK; Harkema, JR; Mauderly, JL;Henderson, RF; Griffith, WC; McClellan, RO. (1988)"<br />
49 Distribution of DNA adducts in the respiratory tract ofrats exposed to diesel exhaust. Toxicol Appl Pharmacol<br />
50 96:336-346.<br />
51<br />
2/1198 10-24 DRAFT--DO NOT CITE OR QUOTE