Health Assessment Document for Diesel Emissions - NSCEP | US ...

1 Caution must be exercised in extrapolating observations made in animal models to
2 . humans when assessing the potential for DE-induced pulmonary carcinogenesis. The
3 carcinogenic response and the formation of DNA adducts in rats exposed to diesel exhaust and
4 other particles at high exposure concentrations may be species-specific and not particle-specific.
5 However, DNA adduct data and the possible involvement of reactive oxygen species maybe
6 relevant in long-term occupational exposure of humans to low concentrations.
7
8 1 0.6. REFERENCES
9
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28 Boldt,J; Mah, MC; Wang, YC; Smith, BA; Beland, FA; Maher, VM; McCormick, JJ. (1991) Kinds of mutations
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33 Washington, DC: Office of Health and Environmental Assessment; EPA/600/R-93/104.
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35 Bond, JA; Mauderly, JL. ( 1984) Metabolism and macromolecular covalent binding of[ 14 C]-l-nitropyrene in isolated
36 . perfused and ventilated rat lungs. Cancer Res 44:3924-3929. ·
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38 Bond, JA; Mitchell, CE; Li, AP. (1983) Metabolism and macromolecular covalent binding ofbenzo[a]pyrene in
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41 Bond, JA; Butler, MM; Medinsky, MA; Muggenburg, BA; McClellan, RO. (1984) Dog pulmonary macrophage
42 metabolism of free and particle-associated [ 14 C]benzo[a]pyrene. J Toxicol Environ Health 14:181-189.
43
44 Bond, JA; Sun, JD; Mitchell, CE; Dutcher, JS; Wolff, RK; McClellan, RO. (1986) Deposition, metabolism and
45 excretion of 14 C-1-nitropyrene coated on diesel particles as influenced by exposure concentration. Toxicol Appl
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48 Bond, JA; Wolff, RK; Harkema, JR; Mauderly, JL;Henderson, RF; Griffith, WC; McClellan, RO. (1988)"
49 Distribution of DNA adducts in the respiratory tract ofrats exposed to diesel exhaust. Toxicol Appl Pharmacol
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51
2/1198 10-24 DRAFT--DO NOT CITE OR QUOTE