Health Assessment Document for Diesel Emissions - NSCEP | US ...

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1 Lewis et al. ( 1989) also examined the effects of inhalation exposure of diesel exhaust 2 and/or coal dust on tumorigenesis on F344 rats. Groups of216 male and 72 female rats were 3 exposed to clean air, whole diesel exhaust (2 mg soot/m 3 ), coal dust (2 mg/m 3 respirable 4 concentration; 5 to 6 mg/m 3 total concentration), or diesel exhaust plus coal dust (1 mg/m 3 of 5 each respirable concentration; 3.2 mg/m 3 total concentration) <strong>for</strong> 7 hlday, 5 days/week <strong>for</strong> up to 6 24 mo. Groups of 10 or more males were sacrificed atintermediate intervals (3, 6, and 12 mo). 7 The diesel exhaust was produced by a 7.0-L, 4-cycle, water-cooled Caterpillar Model3304 8 engine using No.2 diesel fuel (
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DRAFT DO NOT CITE OR QUOTE Health A
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CONTENTS (continued) 2.5.1. Volatil
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CONTENTS (continued) 11.2.1. H.fl.Z
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LIST OF TABLES (continued) 2-14. Me
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PREFACE This draft health assessmen
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AUTHORS, REVIEWERS, AND CONTRIBUTOR
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l. INTRODUCTION 1 Diesel engines ar
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1 achieved by using specific solven
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Nitro-PAH• Table 2-10. Concentrat
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1 pollutants depends on the amount
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1 For the simplest alkoxy radicals,
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1 2 3 4 5 6 7 8 9 10 11 12 13 H ON0
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1 conditions (Pitts et al., 1985c )
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Table 2-14. Mean particle, gas, and
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1 sample collection. There was no b
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1 of downtown Los Angeles (Arey et
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1 exposures. This is a complex ques
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1 Dunstan, TDJ; Mauldin, RF; Jinxia
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1 Lipkea, WH; DeJoode, AD; Christen
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1 Pitts, JN, Jr; Sweetman, JA; Ziel
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1 NOTE TO READERS CHAPTER3 2 Becaus
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1 volume basis (Table 4-1 ). This i
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1 Pritchard (1989), utilizing data
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1 4.3.3.3. Potential Mechanisms for
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1 not accurately reflect the actual
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1 Lee, PS; Chan, TL; Hering, WE. (1
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1 one-half units up to 3, strong (O
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Study Ulfvarson et a!. (1987) Batti
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N -,_. -\0 00 VI N ,_. 0 § I I 0 0
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1 control]). Heinrich et al. (1986a
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1 Heinrich et al. ( 1986a; see also
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1 thoracic area at subsequent times
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1 with matched controls for the num
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----- N \0 00 VI I 0'1 N tJ § I I
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1 In related studies, Navarro et al
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1 Mauderly et al. (1987b) evaluated
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1 pattern of adverse effects on res
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1 DPM concentrations) that resulted
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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1 Klosterkotter, W; Blinemann, G. (
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1 Misiorowski, RL; Strom, KA; Vosta
Page 232: 1 Wright, ES. (1986) Effects of sho
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Page 251 and 252: 1 to derive the RfC. The discussion
Page 253 and 254: 1 The BMC values are the lower 95%
Page 255: Table 6-5. Results of benchmark con
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Page 274 and 275: 1 the latter, 16 were classified as
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Page 285: 1 In a follow-up study, strain A mi
Page 293: 1 In a similar study, 33 four-week-
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1 well as concrete and asphalt work
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1 maximum likelihood method adjusti
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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1 8.4.7. Steineck et al. (1990): In
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N ...... --- \0 ---- 00 00 I VI V
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1 years longer; these workers exhib
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1 from surrogates (next of kin bein
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1 evidence falls just short of bein
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1 Steen land, K. (1986) Lung cancer
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1 and Ouar loci in CHO cells; Curre
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1 Mutagenicity data have been appli
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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10. METABOLISM AND MECHANISM OF ACT
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1 to 107 m 2 ig (organics fully ext
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1 extract of DP\;1 failed to increa
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1 In study by Wolff et al. (1990) d
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1 Lee. KP; Ulrich, CE; Geil, RG; Tr
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1 In the comparative potency method
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1 multiplying by 70, the estimated
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Table 11-4. Incidence of lung tumor
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1 at the doses used, the estimated
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1 though specific particle surface
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1 Garshick, E; Schenker, MB; Munoz,
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1 alveolar regions of the lungs. At
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1 radicals present on the particle
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1 12.3.2.1. Derivation of an Inhala
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1 For convenience EPA has started w
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1 extrapolate risk to low doses. Th
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1 12.3.3.2.4. Assessing risk using
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1 2 3 4 .5 6 7 8 9 10 11 12 13 14 1
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1 Health Effects Institute. (1995)
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APPENDIX A. EXPERIMENTAL PROTOCOL A
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1 B.l. INTRODUCTION 2 As previously
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Parametera llo a b llz qo ql Yo Y1
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Table B-7. Effect of changing dose-
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1 how increase of diesel-exposure c
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1 2 3 4 5 6 7 8 9 10 Given a 2x(x),
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Appendix C Models for Calculating L
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1 respiratory tract by various depo
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1 The values of (DFh and (DF)A over
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1 2 3 4 5 6 7 8 .9 10 direction. Fo
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1 Yu, C.P.; Xu, G.B. (1987) Predict
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