Health Assessment Document for Diesel Emissions - NSCEP | US ...

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AUTHORS, REVIEWERS, AND CONTRIBUTORS (continued) ' . Dr. Joe Mauderly Lovelace Inhalation Research Institute Albuquerque, NM Dr. Roger McClellan Chemical Industries Institute ofToxicology Research Triangle Park, NC Dr. Fred Miller' Duke University Medical Center Durham, NC Dr. Otto Raabe University of California Davis, CA . Mr. Charles Ris National Center for Environmental Assessment U.S. Environmental Protection Agency Washington, DC Dr: Herbert Rosenkranz Department of Environmental Sciences School ofMedicine Case Western University Cleveland, OH Dr. Irving Salmeen Ford Motor Company Scientific Research Laboratory Dearborn,MI Dr. Andrew Sivak Cambridge, MA 2/1198 XX Dr. Jeanette Wiltse National Center for Environmental Assessment U.S. Environmental Protection Agency Washington, DC Dr. Thomas Smith University of Massachusetts Medical Center Worcester, MA · Dr. Frank Speizer Channing Laboratory Boston, MA Dr. Leslie Stayner National Institute for Occupational Safety and Health - Taft Laboratories Cincinnati, OH Dr. Werner Stober Chemical Industries Institute of Toxicology Research Triangle Park, NC Dr. Jaroslav Vostal EHAC International Bloomfield Hills, Ml Dr. James Walker National Center for Environmental Assessment U.S. Environmental Protection Agency Washington, DC DRAFT --DO NOT CITE OR QUOTE
Word Processing Support Ms. Debra Butler · The CDM Group, Inc. Chevy Chase, MD Ms. Glenda Johnson Biomedical and Environmental Information Analysis Health Sciences Research Division Oak Ridge National Laboratory Oak Ridge, TN Document Production Ms. Theresa Konoza National Center for Environmental Assessment U.S. Environmental Protection Agency Washington, DC Ms. Kay Marshall Mr. Eric Sorensen The CDM Group, Inc. Che.vy Chase, MD Ms. Marianne Barrier Mr. John Barton Ms. Sheila Lassiter Ms. Wendy Lloyd Ms. Edie Smith ManTech Environmental Technology, Inc. Research Triangle Park, NC ACKNOWLEDGMENTS 2/1198 XXl References Mr. Douglas Fennell Environmental Criteria and Assessment Office U.S. Environmental Protection Agency Research Triangle Park, NC Ms. Catherine Caner Ms. Blythe Hatcher Information Organizers, Inc. Research Triangle Park, NC Reprographics Mr. Richard Wilson Environmental Criteria and Assessment Office U.S. Environmental Protection Agency Research Triangle Park, NC DRAFT--DO NOT CITE OR QUOTE
Page 1 and 2: DRAFT DO NOT CITE OR QUOTE Health A
Page 4 and 5: CONTENTS (continued) 2.5.1. Volatil
Page 9 and 10: CONTENTS (continued) 11.2.1. H.fl.Z
Page 12: LIST OF TABLES (continued) 2-14. Me
Page 17 and 18: PREFACE This draft health assessmen
Page 22: l. INTRODUCTION 1 Diesel engines ar
Page 42 and 43: 1 achieved by using specific solven
Page 45 and 46: Nitro-PAH• Table 2-10. Concentrat
Page 50: 1 pollutants depends on the amount
Page 56: 1 For the simplest alkoxy radicals,
Page 63 and 64: 1 2 3 4 5 6 7 8 9 10 11 12 13 H ON0
Page 66 and 67: 1 conditions (Pitts et al., 1985c )
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Table 2-14. Mean particle, gas, and
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1 sample collection. There was no b
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1 of downtown Los Angeles (Arey et
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1 exposures. This is a complex ques
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1 Dunstan, TDJ; Mauldin, RF; Jinxia
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1 Lipkea, WH; DeJoode, AD; Christen
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1 Pitts, JN, Jr; Sweetman, JA; Ziel
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1 NOTE TO READERS CHAPTER3 2 Becaus
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1 volume basis (Table 4-1 ). This i
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1 Pritchard (1989), utilizing data
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1 4.3.3.3. Potential Mechanisms for
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1 not accurately reflect the actual
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1 Lee, PS; Chan, TL; Hering, WE. (1
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1 one-half units up to 3, strong (O
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Study Ulfvarson et a!. (1987) Batti
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N -,_. -\0 00 VI N ,_. 0 § I I 0 0
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1 control]). Heinrich et al. (1986a
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1 Heinrich et al. ( 1986a; see also
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1 thoracic area at subsequent times
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1 with matched controls for the num
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----- N \0 00 VI I 0'1 N tJ § I I
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1 In related studies, Navarro et al
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1 Mauderly et al. (1987b) evaluated
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1 pattern of adverse effects on res
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1 DPM concentrations) that resulted
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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1 Klosterkotter, W; Blinemann, G. (
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1 Misiorowski, RL; Strom, KA; Vosta
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1 Wright, ES. (1986) Effects of sho
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1 Studies showing these effects are
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1 exposure level. In the 0.3 5 mg/m
Page 251 and 252:
1 to derive the RfC. The discussion
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1 The BMC values are the lower 95%
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Table 6-5. Results of benchmark con
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1 U.S. Environmental Protection Age
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1 the latter, 16 were classified as
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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1 burdens of the NMRI mice after 12
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1 with four to seven rings), which
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1 five daily doses of2,000 f...lg.
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1 occupations. The observed absence
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1 occupations). Analysis was conduc
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1 the confined space of a truck cab
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1 The corresponding odds ratios for
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1 Approximately 20,000 miners are e
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1 bladder cancer was found in Canad
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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1 Kaplan, I. (1959) Relationship of
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9. MUTAGENICITY 1 Since 1978, more
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1 the presence of heritable translo
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1 9.5. REFERENCES 2 3 "Barfknecht,
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1 U.S. Environmental Protection Age
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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1 inconsequential in rats relative
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1 response. cell injury, or cell pr
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1 Caution must be exercised in extr
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1 Rister, M: Baehner, RL. ( 1977) E
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1 The potency of the other diesel e
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Table 11-2. Incidence of lung tumor
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Table 11-5. Unit risk estimates per
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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1 to reflect the potency of several
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1 Huisingh. J; Bradow, R; Jungers,
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1 particles are fine and ultrafine
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1 are available. Exposure is most o
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1 · some of which can be informed
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1 For example, in a recent meta-ana
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1 nonthreshold-mutagen driven MOA.
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1 that their developing pulmonary a
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1 impacts. Use of these measures re
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2/1198 Appendix A Experimental Prot
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APPENDIX A. EXPERIMENTAL PROTOCOL A
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Page 511 and 512:
Page 513 and 514:
2/1198 Appendix B Alternative Model
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1 d: Dose of organics, mg/cm 2 of l
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Table B-4. Comparison of observed t
Page 526 and 527:
1 uncertainties below). Based on th
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1 B.lO. RFERENCES 2 3 Bohning D., A
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1 and 2 m.(t) = (y2i - YI/exp[Ap)a/
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1 C.l. INTRODUCTION 2 As discussed
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1 For mouth breathing: 2 (DF)H . =
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TABLE C-1. LUNG MODEL FOR RATS AT T
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TABLE C-3. RATIO OF PULMONARY SURFA
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