Health Assessment Document for Diesel Emissions - NSCEP | US ...

More documents

Recommendations

Info

1 exposed to 0.15, 0.94, or 4.1 mg DPM/m 3 were sacrificed at 1 day and 1, 5, 15, 33, and 52 weeks 2 after exposure, and DPM was extracted from lung tissue dissolved in tetramethylammonium 3 hydroxide. Following centrifugation and washing of the supernatant, DPM content of the tissue 4 was quantitated using spectrophotometric techniques. The analytical procedure was verified by 5 comparing results to recovery studies using known amounts of DPM with lungs of unexposed 6 rats. Long-term retention <strong>for</strong> the 0.15 and 0.94 mg/m 3 groups had estimated half-times of 87 ± 7 28 and 99 ± 8 days, respectively. The retention t 112 <strong>for</strong> the 4.1-mg/m 3 exposure group was 165 ± · 8 8 days, which was significantly (p
Page 1 and 2:
DRAFT DO NOT CITE OR QUOTE Health A
Page 4 and 5:
CONTENTS (continued) 2.5.1. Volatil
Page 9 and 10:
CONTENTS (continued) 11.2.1. H.fl.Z
Page 12:
LIST OF TABLES (continued) 2-14. Me
Page 17 and 18:
PREFACE This draft health assessmen
Page 20 and 21:
AUTHORS, REVIEWERS, AND CONTRIBUTOR
Page 22:
l. INTRODUCTION 1 Diesel engines ar
Page 42 and 43:
1 achieved by using specific solven
Page 45 and 46:
Nitro-PAH• Table 2-10. Concentrat
Page 50:
1 pollutants depends on the amount
Page 56: 1 For the simplest alkoxy radicals,
Page 63 and 64: 1 2 3 4 5 6 7 8 9 10 11 12 13 H ON0
Page 66 and 67: 1 conditions (Pitts et al., 1985c )
Page 69: Table 2-14. Mean particle, gas, and
Page 72 and 73: 1 sample collection. There was no b
Page 75: 1 of downtown Los Angeles (Arey et
Page 81: 1 exposures. This is a complex ques
Page 85: 1 Dunstan, TDJ; Mauldin, RF; Jinxia
Page 88 and 89: 1 Lipkea, WH; DeJoode, AD; Christen
Page 90: 1 Pitts, JN, Jr; Sweetman, JA; Ziel
Page 95: 1 NOTE TO READERS CHAPTER3 2 Becaus
Page 101: 1 volume basis (Table 4-1 ). This i
Page 114 and 115: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Page 122 and 123: 1 4.4.3. Extraction of Diesel Parti
Page 128: 1 particulate matter is considered
Page 132: 1 Ohkuma, S; Poole, B. ( 1978) Fluo
Page 147 and 148: Study Diaz-Sanchez et al. (1996) Di
Page 150: Study Edling and Axelson (1984) Edl
Page 158:
1 caused by cellular damage resulti
Page 166:
1 monkeys there were no specific hi
Page 176:
1 on the following evidence. The ep
Page 188 and 189:
1 S. typhimurium were inconclusive
Page 191:
1 diesel exhaust on the immune syst
Page 197:
1 serum enzymes in the control vers
Page 203:
1 the differences were the result o
Page 215 and 216:
1 effects occur at lower doses than
Page 217 and 218:
1 definitive conclusions as to the.
Page 220 and 221:
1 5.6.2.6. Other Noncancerous Effec
Page 224:
1 Garg, BD. (1983) Histologic quant
Page 227 and 228:
1 Lewis, TR; Campbell, KI; Vaughan,
Page 229:
1 Pepelko, WE. ( 1982b) EPA studies
Page 234 and 235:
1 EPA, 1995a). The BMC approach, ap
Page 237 and 238:
1 was decided to use a default part
Page 250 and 251:
1 be varied (for example, by includ
Page 252 and 253:
Table 6-3. Results of benchmark con
Page 254 and 255:
1 the Ishinishi et al. (1988) study
Page 261 and 262:
1 Mauderly, JL; Jones, RK; Griffith
Page 272:
1 respectively). Bronchoalveolar ad
Page 275:
1 adenocarcinomas (1311 00) were si
Page 280:
1 Lewis et al. ( 1989) also examine
Page 285:
1 In a follow-up study, strain A mi
Page 293:
1 In a similar study, 33 four-week-
Page 336:
1 well as concrete and asphalt work
Page 343:
1 maximum likelihood method adjusti
Page 355 and 356:
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Page 363 and 364:
1 8.4.7. Steineck et al. (1990): In
Page 365:
N ...... --- \0 ---- 00 00 I VI V
Page 371:
1 years longer; these workers exhib
Page 376 and 377:
1 from surrogates (next of kin bein
Page 380:
1 evidence falls just short of bein
Page 383:
1 Steen land, K. (1986) Lung cancer
Page 387:
1 and Ouar loci in CHO cells; Curre
Page 390 and 391:
1 Mutagenicity data have been appli
Page 392:
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Page 395:
10. METABOLISM AND MECHANISM OF ACT
Page 398 and 399:
1 to 107 m 2 ig (organics fully ext
Page 406:
1 extract of DP\;1 failed to increa
Page 415:
1 In study by Wolff et al. (1990) d
Page 422:
1 Lee. KP; Ulrich, CE; Geil, RG; Tr
Page 431 and 432:
1 In the comparative potency method
Page 435:
1 multiplying by 70, the estimated
Page 440 and 441:
Table 11-4. Incidence of lung tumor
Page 443 and 444:
1 at the doses used, the estimated
Page 447:
1 though specific particle surface
Page 451 and 452:
1 Garshick, E; Schenker, MB; Munoz,
Page 460:
1 alveolar regions of the lungs. At
Page 464 and 465:
1 radicals present on the particle
Page 471:
1 12.3.2.1. Derivation of an Inhala
Page 475:
1 For convenience EPA has started w
Page 478 and 479:
1 extrapolate risk to low doses. Th
Page 480:
1 12.3.3.2.4. Assessing risk using
Page 486:
1 2 3 4 .5 6 7 8 9 10 11 12 13 14 1
Page 494 and 495:
1 Health Effects Institute. (1995)
Page 503 and 504:
APPENDIX A. EXPERIMENTAL PROTOCOL A
Page 505:
Page 509:
Page 512 and 513:
Page 514:
1 B.l. INTRODUCTION 2 As previously
Page 519:
Parametera llo a b llz qo ql Yo Y1
Page 524:
Table B-7. Effect of changing dose-
Page 527:
1 how increase of diesel-exposure c
Page 532:
1 2 3 4 5 6 7 8 9 10 Given a 2x(x),
Page 538 and 539:
Appendix C Models for Calculating L
Page 540:
1 respiratory tract by various depo
Page 551 and 552:
1 The values of (DFh and (DF)A over
Page 555:
1 2 3 4 5 6 7 8 .9 10 direction. Fo
Page 575:
1 Yu, C.P.; Xu, G.B. (1987) Predict
show all

Health Assessment Document for Diesel Emissions - NSCEP | US ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?