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Quantitative Sensory Testing (QST) - Does assessing ... - TI Pharma

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Contents<br />

3.4. Number of sensory abnormalities in relation to neuropathic pain grading<br />

3.5. Background pain in relation to neuropathic pain grading<br />

4. Discussion<br />

4.1. Clinical diagnoses and grading of neuropathic pain<br />

4.2. Somatosensory function in healthy controls<br />

4.3. Somatosensory function in neuropathic pain patients<br />

4.3.1. Somatosensory function across the grading of neuropathic pain<br />

4.4. Background pain, number of sensory abnormalities and neuropathic<br />

pain grading<br />

Acknowledgement<br />

Chapter 4<br />

A single <strong>QST</strong> parameter as a tool for mechanism-based investigation<br />

of neuropathic pain<br />

Abstract<br />

1. Introduction<br />

2. Method<br />

2.1. Description of healthy controls<br />

2.2. Description of the patient cohort<br />

2.3. <strong>Quantitative</strong> sensory testing (<strong>QST</strong>)<br />

2.4. Data analysis and statistics<br />

2.4.1. Z-transformation of <strong>QST</strong> data<br />

2.4.2. Stimulus-response function for MPS in patients<br />

2.4.3. Statistical analyses<br />

3. Results<br />

3.1. Stimulus-response function in healthy subjects<br />

3.2. Z-score transformation for MPS in patients<br />

3.3. Differences in pattern of stimulus-response function<br />

3.4. Clinical diagnoses of patients with MPS abnormalities and<br />

different stimulus-response functions for pinpricks<br />

4. Discussion<br />

4.1. MPS abnormalities in neuropathic pain patients<br />

4.2. Stimulus-response function for pinprick<br />

4.3. <strong>QST</strong> for mechanism-based studies in neuropathic pain patients<br />

Acknowledgement<br />

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