Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...

Table 67 Patient criteria of included studies focusing on the use of HBOT in cervical cancer.
First Author and Year
of Publication
Brady 1981 108
Watson 1978 109
Fletcher 1977 110
Glassburn 1974 111
Patient Criteria
Patients with squamous cell carcinoma of the cervix (stage IIb, IIIa, IIIb, IVa, International
Federation of Gynecology and Obstetrics).
Exclusions: pregnancy; previous radiotherapy to the primary site; previous surgery or
chemotherapy; prior diagnosis of malignancy other than skin cancer.
Patients aged 75 years of less with locally advanced carcinoma of the cervix (stages III and
IVa, Stockholm) proven histologically; ability to lie flat and be otherwise fit for treatment in a
HBO chamber; no previous treatment with radium.
Exceptions: 23 patients with stage IIb cancer included in one centre.
Patients with stage IIb (involvement of the lateral half of the parametria without involvement
of the pelvic walls or the lower third of the vagina), IIIa (fixation to one pelvic wall), IIIb
(fixation to both pelvic walls or involvement of one pelvic wall and the lower third of the
vagina), and IVa (biopsy-proven bladder or rectal involvement without distant metastases)
carcinoma of the cervix.
Exclusion: patients over 70 years of age.
Exceptions: 10 patients with stage I-IIa cancer included.
Patients with stage 3a, 3b or 4a carcinoma of the cervix.
Exclusions: receipt of prior therapy for cervical carcinoma; second primary tumour other than
cancer of the skin; pre-existing medical problems preventing treatment with HBO.
Johnson 1974 112 Patients with stage III or IV carcinoma of the cervix.
Ward 1974 113
Patients with clinically (League of Nations) staged 2b or 3 cancers of the uterine cervix;
diagnosis histologically confirmed before treatment; not pregnant; no history of major pelvic
surgery or pelvic irradiation, salpingitis, or endometriosis; physically and psychologically
suitable for treatment in HBO; haemoglobin of at least 80 percent before treatment; no history
of malignant disease; 75 years of age or less.
Interventions examined
The HBO protocols used in intervention therapies were not described in three studies
(Table 68). 109,110,112 In those reporting use of HBO, inadequate information was given
about chambers, duration, or frequencies.
68 Hyperbaric oxygen therapy