Hyperbaric Oxygen Therapy - Hyperbaric Chamber Information ...

Table 64 Therapeutic protocols used in intervention and comparison groups in included studies
focusing on the use of HBOT in head and neck cancer.*
First Author and Year of
Publication Intervention Group Comparison Group
Whittle 1990 99 n=157
Placement in a monoplace HBO chamber at 3
ATA up to one hour, plus concurrent
radiotherapy at a dose of 32-34 Gy in six
fractions over 18 days.
Henk 1986 100 n=54
Placement in a HBOT chamber, pressure and
time not stated. Dosage and fractionation
scheme for radiotherapy was 3600-4500 rad in
10 fractions in 22 days.
Sealy 1986 101 n=64
Radiotherapy in HBOT. Radiotherapy dose of
36.0 Gy in six fractions over 17 days.
Misonidazole (2.0g/m2 p.o. per fraction) was
also prescribed and HBOT at 3 ATA.
Berry 1979 102 n=9
Radiotherapy concurrent with HBOT; dose of
radiotherapy was 4000-4500 rad (reduced to
3650-4150 rad in the larynx was involved) in
10 fractions.
Sause 1979 103 n=21
Radiation therapy: 12 х 400 rad in 32 days
during concurrent HBOT at 3 ATA.
Chang 1973 104 n=26
Radiotherapy at a dose of 600 rad x 6
treatments (two per week for three weeks),
concurrently with HBOT at 3 ATA.
Churchill-Davidson
1973 105
n=102
HBOT at 3-4 ATA with radiotherapy at a
maximum dose of 3600 rads in six fractions
over 18-19 days.
Shigamatsu 1973 106 n=21
Radiotherapy concurrent with HBOT at 3 ATA
in a monoplace chamber. Radiotherapy
consisted of a total dose of 6000-7000 R in a
bi-weekly schedule.
Henk 1970 107 n=101
Radiotherapy received concurrent to HBOT at
3 ATA in a monoplace chamber. Radiotherapy
at a dose of 3500-4500 rads in 10 fractions
over three weeks.
* Abbreviations: ATA = atmosphere absolute, n = sample size
† Therapy not described.
n=240
Conventional radiotherapy in air at a dose
of 60-70 Gy, five fractions per week.
n=53
Conventional radiotherapy in air: 30
fractions over six weeks; dosage received
was 6400 rad (proportionally smaller
when fields were larger).
n=66
Conventional radiotherapy in air: tumour
dose of 63.0 Gy in 30 fractions daily over
38 days.
n=15
Conventional radiotherapy in air: 4450-
5000 rad in 15 fractions or 4850-5500 rad
in 20 fractions depending on field size.
n=23
Conventional radiotherapy (250-6250 rad)
in air.
n=25
Control group 1: n=12 received
radiotherapy in air at a dose of 600 rads
per treatment for seven treatments (two
per week for 3.5 weeks).
Control group 2: n=13 received
radiotherapy at 200 rads per treatment for
30 treatments (five per week for six
weeks).
n=69
Radiotherapy treatment in air. †
n=21
Radiotherapy in air, 4000-5000 R in 9-10
fractions.
n=112
Radiotherapy in air: 3500-4500 rads in 10
equal fractions, over three weeks.
The disparities in intervention protocols were reflected in equally varied comparison
protocols. Doses and fractionation schemes varied between the intervention and
Hyperbaric oxygen therapy 65